Seroatlas · Human Serome Atlas

RFESD

Rieske domain-containing protein

Also known as: RFESD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAC1
Gene
RFESD
Ensembl
ENSG00000175449
Chromosome
5
Canonical length
157 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable 2 iron, 2 sulfur cluster binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>Q8TAC1|RFESD
     1  MNLDGSAQDP EKREYSSVCV GREDDIKKSE RMTAVVHDRE VVIFYHKGEY HAMDIRCYHS
    61  GGPLHLGDIE DFDGRPCIVC PWHKYKITLA TGEGLYQSIN PKDPSAKPKW CSKGIKQRIH
   121  TVTVDNGNIY VTLSNEPFKC DSDFYATGDF KVIKSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFESD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 17 nTPM
  • testis: 12 nTPM
  • skin: 4.6 nTPM
  • skeletal muscle: 4.5 nTPM
  • epididymis: 3.8 nTPM
  • pancreas: 3.4 nTPM

Single-cell type

  • oocytes: 180 nCPM
  • erythrocyte progenitors: 138 nCPM
  • adipocytes: 81 nCPM
  • late primary spermatocytes: 52 nCPM
  • mast cells: 42 nCPM
  • erythrocytes: 35 nCPM

Immune cell

  • naive CD4 T-cell: 7.7 nTPM
  • MAIT T-cell: 5.9 nTPM
  • memory CD4 T-cell: 5.1 nTPM
  • naive CD8 T-cell: 4.6 nTPM
  • memory CD8 T-cell: 3.6 nTPM
  • NK-cell: 3.5 nTPM

Brain region

  • cerebellum: 2.7 nTPM
  • white matter: 2.5 nTPM
  • medulla oblongata: 2.4 nTPM
  • choroid plexus: 2.3 nTPM
  • pons: 2.1 nTPM
  • basal ganglia: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
0.91
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFESD as an antibody target. Whether an autoantibody or antibody against RFESD could matter depends on whether native RFESD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFESD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFESD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RFESD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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