REX1BD
Required for excision 1-B domain-containing protein
Also known as: C19orf60, FLJ20850, FLJ30108, FLJ34606, FLJ37391, REX1B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96EN9
- Gene
- REX1BD
- Ensembl
- ENSG00000006015
- Chromosome
- 19
- Canonical length
- 201 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
No narrative summary is available for REX1BD in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
201 residues, UniProt reviewed canonical sequence.
>Q96EN9|REX1BD
1 MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA ERAQGFRRLE
61 EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY RSTVHGVTQA FAAASREVLA
121 VEAELGGPRR QPLLAGHVRS LQELEQTRLG TVALLQLMET PELAGQEDAV RMQQLKMKVI
181 KTMEAISEVL QDLRFDAESA ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against REX1BD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 109 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 109 nTPM
- cerebral cortex: 89 nTPM
- amygdala: 85 nTPM
- heart muscle: 79 nTPM
- basal ganglia: 76 nTPM
- hippocampal formation: 75 nTPM
Single-cell type
- hofbauer cells: 340 nCPM
- hepatocytes: 253 nCPM
- extravillous trophoblasts: 193 nCPM
- enterocytes: 188 nCPM
- colonocytes: 187 nCPM
- decidual stromal cells: 167 nCPM
Immune cell
- MAIT T-cell: 153 nTPM
- eosinophil: 153 nTPM
- memory CD4 T-cell: 152 nTPM
- classical monocyte: 151 nTPM
- gdT-cell: 149 nTPM
- myeloid DC: 147 nTPM
Brain region
- thalamus: 60 nTPM
- cerebral cortex: 58 nTPM
- medulla oblongata: 58 nTPM
- amygdala: 57 nTPM
- hypothalamus: 57 nTPM
- white matter: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.44
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Required for excision 1-B domain-containing protein
- DNA repair REX1-B
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads REX1BD as an antibody target. Whether an autoantibody or antibody against REX1BD could matter depends on whether native REX1BD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
REX1BD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label REX1BD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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