Seroatlas · Human Serome Atlas

RETSAT

All-trans-retinol 13,14-reductase

Also known as: FLJ20296, RETST_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NUM9
Gene
RETSAT
Ensembl
ENSG00000042445
Chromosome
2
Canonical length
610 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable all-trans-retinol 13,14-reductase activity. Predicted to be involved in retinol metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q6NUM9|RETSAT
     1  MWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA RKKVLKQAFS
    61  ANQVPEKLDV VVIGSGFGGL AAAAILAKAG KRVLVLEQHT KAGGCCHTFG KNGLEFDTGI
   121  HYIGRMEEGS IGRFILDQIT EGQLDWAPLS SPFDIMVLEG PNGRKEYPMY SGEKAYIQGL
   181  KEKFPQEEAI IDKYIKLVKV VSSGAPHAIL LKFLPLPVVQ LLDRCGLLTR FSPFLQASTQ
   241  SLAEVLQQLG ASSELQAVLS YIFPTYGVTP NHSAFSMHAL LVNHYMKGGF YPRGGSSEIA
   301  FHTIPVIQRA GGAVLTKATV QSVLLDSAGK ACGVSVKKGH ELVNIYCPIV VSNAGLFNTY
   361  EHLLPGNARC LPGVKQQLGT VRPGLGMTSV FICLRGTKED LHLPSTNYYV YYDTDMDQAM
   421  ERYVSMPREE AAEHIPLLFF AFPSAKDPTW EDRFPGRSTM IMLIPTAYEW FEEWQAELKG
   481  KRGSDYETFK NSFVEASMSV VLKLFPQLEG KVESVTAGSP LTNQFYLAAP RGACYGADHD
   541  LGRLHPCVMA SLRAQSPIPN LYLTGQDIFT CGLVGALQGA LLCSSAILKR NLYSDLKNLD
   601  SRIRAQKKKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RETSAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
232 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 232 nTPM
  • duodenum: 157 nTPM
  • small intestine: 134 nTPM
  • liver: 108 nTPM
  • colon: 84 nTPM
  • rectum: 69 nTPM

Single-cell type

  • enterocytes: 271 nCPM
  • adipocytes: 218 nCPM
  • colonocytes: 206 nCPM
  • melanocytes: 105 nCPM
  • myonuclei: 94 nCPM
  • foveolar cells: 86 nCPM

Immune cell

  • non-classical monocyte: 8.8 nTPM
  • MAIT T-cell: 6.3 nTPM
  • memory CD8 T-cell: 6 nTPM
  • NK-cell: 5.2 nTPM
  • gdT-cell: 4.8 nTPM
  • T-reg: 4.2 nTPM

Brain region

  • choroid plexus: 53 nTPM
  • white matter: 44 nTPM
  • medulla oblongata: 39 nTPM
  • basal ganglia: 39 nTPM
  • thalamus: 38 nTPM
  • hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • all-trans-retinol 13
  • 14-reductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RETSAT as an antibody target. Whether an autoantibody or antibody against RETSAT could matter depends on whether native RETSAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RETSAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RETSAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RETSAT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...