RETNLB
Resistin-like beta
Also known as: FIZZ2, HXCP2, RELMb, RETNB_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQ08
- Gene
- RETNLB
- Ensembl
- ENSG00000163515
- Chromosome
- 3
- Canonical length
- 111 aa
- Protein class
- Predicted secreted proteins, Transporters
- Subcellular location
- Endoplasmic reticulum
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to enable hormone activity. Involved in epithelial cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>Q9BQ08|RETNLB
1 MGPSSCLLLI LIPLLQLINP GSTQCSLDSV MDKKIKDVLN SLEYSPSPIS KKLSCASVKS
61 QGRPSSCPAG MAVTGCACGY GCGSWDVQLE TTCHCQCSVV DWTTARCCHL TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RETNLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 217 nTPM
Expression across tissuesHPA
Tissue
- rectum: 217 nTPM
- colon: 67 nTPM
- small intestine: 33 nTPM
- duodenum: 15 nTPM
- appendix: 3.7 nTPM
- smooth muscle: 0.7 nTPM
Single-cell type
- goblet cells: 178 nCPM
- enteric transient amplifying cells: 9.6 nCPM
- enteric stem cells: 9.5 nCPM
- late spermatids: 7.1 nCPM
- cone photoreceptor cells: 4.1 nCPM
- cardiomyocytes: 4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.74
- gnomAD pLI
- 0.04
- gnomAD missense Z
- -0.25
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RETNLB as an antibody target. Whether an autoantibody or antibody against RETNLB could matter depends on whether native RETNLB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RETNLB is annotated as secreted, so native RETNLB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label RETNLB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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