Seroatlas · Human Serome Atlas

RETN

Resistin

Also known as: ADSF, FIZZ3, RETN_HUMAN, RETN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD89
Gene
RETN
Ensembl
ENSG00000104918
Chromosome
19
Canonical length
108 aa
Protein class
Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>Q9HD89|RETN
     1  MKALCLLLLP VLGLLVSSKT LCSMEEAINE RIQEVAGSLI FRAISSIGLE CQSVTSRGDL
    61  ATCPRGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG ARCCRVQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RETN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
233 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 233 nTPM
  • spleen: 57 nTPM
  • lung: 35 nTPM
  • duodenum: 5.7 nTPM
  • appendix: 4.9 nTPM
  • smooth muscle: 4 nTPM

Single-cell type

  • neutrophil progenitors: 3,157 nCPM
  • monocyte progenitors: 596 nCPM
  • neutrophils: 267 nCPM
  • hofbauer cells: 218 nCPM
  • monocytes: 163 nCPM
  • macrophages: 34 nCPM

Immune cell

  • classical monocyte: 171 nTPM
  • myeloid DC: 119 nTPM
  • intermediate monocyte: 92 nTPM
  • total PBMC: 64 nTPM
  • non-classical monocyte: 48 nTPM
  • neutrophil: 14 nTPM

Brain region

  • cerebral cortex: 2.8 nTPM
  • basal ganglia: 1 nTPM
  • hypothalamus: 1 nTPM
  • amygdala: 0.9 nTPM
  • hippocampal formation: 0.9 nTPM
  • pons: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0.04
gnomAD missense Z
0.12
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RETN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RETN as an antibody target. Whether an autoantibody or antibody against RETN could matter depends on whether native RETN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RETN is annotated as secreted, so native RETN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RETN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RETN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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