Seroatlas · Human Serome Atlas

RESP18

Regulated endocrine-specific protein 18

Also known as: RES18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W5W9
Gene: RESP18
Ensembl: ENSG00000182698
Chromosome: 2
Canonical length: 228 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to act upstream of or within in utero embryonic development. Predicted to be located in Golgi apparatus and cytoplasmic vesicle. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q5W5W9|RESP18
     1  MAVDVEFGVA GWWEAAAPLS PSAVAATFTE TWPGSERAEP GRIQHPLWPG SSEGLQLLVC
    61  FLLLNSCPGG CSDTSAHDGQ DQVGVGQLWP LQGFATPVFQ HLQVVLQQII PQGLFWKDDI
   121  TQDAMIQKME HASRLHPQEP CLKDGKALFP TKTTESPLAK VNRDQCFTSE VVSKALKQEV
   181  ANPVKITYRC SYGGLDMMQA PGPSKEEIIY KIMRLLWATS YCGPQPCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RESP18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 46 nTPM
hypothalamus: 8.3 nTPM
midbrain: 7.9 nTPM
hippocampal formation: 6.9 nTPM
amygdala: 5 nTPM
cerebral cortex: 3.2 nTPM

Single-cell type

late spermatids: 56 nCPM
early spermatids: 11 nCPM
late primary spermatocytes: 4.9 nCPM
other brain neurons: 3.5 nCPM
brain inhibitory neurons: 3.1 nCPM
brain excitatory neurons: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 29 nTPM
hypothalamus: 9.9 nTPM
midbrain: 9.6 nTPM
hippocampal formation: 8.6 nTPM
pons: 7 nTPM
cerebral cortex: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

RESP18 domain
RESP18 domain
Regulated endocrine-specific protein 18

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RESP18 as an antibody target. Whether an autoantibody or antibody against RESP18 could matter depends on whether native RESP18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RESP18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RESP18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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