Seroatlas · Human Serome Atlas

RESF1

Retroelement silencing factor 1

Also known as: C12orf35, FLJ10652, FLJ20696, GET, KIAA1551, RESF1_HUMAN, UTA2-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCM1
Gene: RESF1
Ensembl: ENSG00000174718
Chromosome: 12
Canonical length: 1747 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to enable histone binding activity and histone methyltransferase binding activity. Predicted to be involved in transposable element silencing by heterochromatin formation. Predicted to act upstream of or within response to bacterium. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1747 residues, UniProt reviewed canonical sequence.

>Q9HCM1|RESF1
     1  MNWNEKPKSA TLPPLYPKSQ PPFLHQSLIN QITTTSQSSF SYPGSNQEAC MYPGNSNPIS
    61  QPLLNIQNYP QQISVSDMHN GTVVASHTSV ERITYANVNG PKQLTHNLQM SSGVTQNVWL
   121  NSPMRNPVHS HIGATVSHQT DFGANVPNMP ALQSQLITSD TYSMQMQMIP SNSTRLPVAY
   181  QGNQGLNQSF SEQQVDWTQQ CISKGLTYPD YRPPPKLYRY SPQSFLPDST IQKQNFIPHT
   241  SLQVKNSQLL NSVLTLPSRQ TSAVPSQQYA TQTDKRPPPP PYNCRYGSQP LQSTQHITKH
   301  LSMEVPQSRE MLSSEIRTSF QQQWQNPNEN VSTIGNFTNL KVNTNSKQPF NSPIRSSVDG
   361  VQTLAQTNEE KIMDSCNPTS NQVLDTSVAK EKLVRDIKTL VEIKQKFSEL ARKIKINKDL
   421  LMAAGCIKMT NTSYSEPAQN SKLSLKQTAK IQSGPQITPV MPENAERQTP TVVESAETNK
   481  TQCMLNSDIQ EVNCRRFNQV DSVLPNPVYS EKRPMPDSSH DVKVLTSKTS AVEMTQAVLN
   541  TQLSSENVTK VEQNSPAVCE TISVPKSMST EEYKSKIQNE NMLLLALLSQ ARKTQKTVLK
   601  DANQTIQDSK PDSCEMNPNT QMTGNQLNLK NMETPSTSNV SGRVLDNSFC SGQESSTKGM
   661  PAKSDSSCSM EVLATCLSLW KKQPSDTAKE KECDKLRTNT TAVGISKPAN IHVKSPCSVV
   721  GNSNSQNKIS NPSQQTALSM VMHNYESSGI NITKGTELQI AVVSPLVLSE VKTLSVKGIT
   781  PAVLPETVYP VIKEGSVCSL QNQLAENAKA TAALKVDVSG PVASTATSTK IFPLTQKEKQ
   841  NESTNGNSEV TPNVNQGKHN KLESAIHSPM NDQQISQESR NSTVVSSDTL QIDNICSLVE
   901  GDTSYNSQIA KIFSSLPLKM VEPQKPSLPN QQGIGSREPE KQLDNTTENK DFGFQKDKPV
   961  QCTDVSHKIC DQSKSEPPLE SSFNNLETNR VILEKSSLEH ATEKSTANDT CSSAAIQEDI
  1021  YPQEIDASSN YTPQDPARNE IHSDKAPVLY LHDQLSELLK EFPYGIEAVN TREGSVGQQT
  1081  TYQTSEDQTA DKTSSDSKDP ADQIQITILS SEQMKEIFPE QDDQPYVVDK LAEPQKEEPI
  1141  TEVVSQCDLQ APAAGQSRDS VILDSEKDDI HCCALGWLSM VYEGVPQCQC NSIKNSSSEE
  1201  EKQKEQCSPL DTNSCKQGER TSDRDVTVVQ FKSLVNNPKT PPDGKSHFPE LQDDSRKDTP
  1261  KTKHKSLPRT EQELVAGQFS SKCDKLNPLQ NHKRKKLRFH EVTFHSSNKM TASYEQASQE
  1321  TRQKKHVTQN SRPLKTKTAF LPNKDVYKKH SSLGQSLSPE KIKLKLKSVS FKQKRKLDQG
  1381  NVLDMEVKKK KHDKQEQKGS VGATFKLGDS LSNPNERAIV KEKMVSNTKS VDTKASSSKF
  1441  SRILTPKEYL QRQKHKEALS NKASKKICVK NVPCDSEHMR PSKLAVQVES CGKSNEKHSS
  1501  GVQTSKESLN GLTSHGKNLK IHHSQESKTY NILRNVKEKV GGKQPDKIWI DKTKLDKLTN
  1561  ISNEAQFSQM PPQVKDQKKL YLNRVGFKCT ERESISLTKL ESSPRKLHKD KRQENKHKTF
  1621  LPVKGNTEKS NMLEFKLCPD ILLKNTNSVE ERKDVKPHPR KEQAPLQVSG IKSTKEDWLK
  1681  FVATKKRTQK DSQERDNVNS RLSKRSFSAD GFEMLQNPVK DSKEMFQTYK QMYLEKRSRS
  1741  LGSSPVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RESF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

lymph node: 66 nTPM
ovary: 65 nTPM
tonsil: 59 nTPM
thymus: 57 nTPM
appendix: 48 nTPM
spleen: 43 nTPM

Single-cell type

neutrophils: 2,512 nCPM
t-cells: 397 nCPM
ocular epithelial cells: 346 nCPM
b-cells: 287 nCPM
nk-cells: 217 nCPM
innate lymphoid cells: 215 nCPM

Immune cell

neutrophil: 215 nTPM
basophil: 56 nTPM
naive CD4 T-cell: 44 nTPM
naive CD8 T-cell: 44 nTPM
gdT-cell: 42 nTPM
memory CD8 T-cell: 41 nTPM

Brain region

cerebral cortex: 37 nTPM
cerebellum: 29 nTPM
pons: 24 nTPM
white matter: 23 nTPM
medulla oblongata: 22 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.01
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transposable element silencing by heterochromatin formation

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Retroelement silencing factor 1
Domain of unknown function (DUF4617)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RESF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SETDB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RESF1 as an antibody target. Whether an autoantibody or antibody against RESF1 could matter depends on whether native RESF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RESF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RESF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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