Seroatlas · Human Serome Atlas

REPIN1

DNA-binding protein REPIN1

Also known as: AP4, H_DJ0584D14.12, REPI1_HUMAN, RIP60, Zfp464, ZNF464

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BWE0
Gene
REPIN1
Ensembl
ENSG00000214022
Chromosome
7
Canonical length
567 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of fatty acid transport and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of D-glucose import. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q9BWE0|REPIN1
     1  MLERRCRGPL AMGLAQPRLL SGPSQESPQT LGKESRGLRQ QGTSVAQSGA QAPGRAHRCA
    61  HCRRHFPGWV ALWLHTRRCQ ARLPLPCPEC GRRFRHAPFL ALHRQVHAAA TPDLGFACHL
   121  CGQSFRGWVA LVLHLRAHSA AKRPIACPKC ERRFWRRKQL RAHLRRCHPP APEARPFICG
   181  NCGRSFAQWD QLVAHKRVHV AEALEEAAAK ALGPRPRGRP AVTAPRPGGD AVDRPFQCAC
   241  CGKRFRHKPN LIAHRRVHTG ERPHQCPECG KRFTNKPYLT SHRRIHTGEK PYPCKECGRR
   301  FRHKPNLLSH SKIHKRSEGS AQAAPGPGSP QLPAGPQESA AEPTPAVPLK PAQEPPPGAP
   361  PEHPQDPIEA PPSLYSCDDC GRSFRLERFL RAHQRQHTGE RPFTCAECGK NFGKKTHLVA
   421  HSRVHSGERP FACEECGRRF SQGSHLAAHR RDHAPDRPFV CPDCGKAFRH KPYLAAHRRI
   481  HTGEKPYVCP DCGKAFSQKS NLVSHRRIHT GERPYACPDC DRSFSQKSNL ITHRKSHIRD
   541  GAFCCAICGQ TFDDEERLLA HQKKHDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REPIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
126 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 126 nTPM
  • liver: 83 nTPM
  • adrenal gland: 72 nTPM
  • pituitary gland: 65 nTPM
  • pancreas: 64 nTPM
  • colon: 63 nTPM

Single-cell type

  • adipocytes: 5.1 nCPM
  • cardiomyocytes: 2.7 nCPM
  • granulosa cells: 0.8 nCPM
  • thymocytes: 0.8 nCPM
  • enterocytes: 0.7 nCPM
  • late spermatids: 0.7 nCPM

Immune cell

  • plasmacytoid DC: 7.8 nTPM
  • eosinophil: 2.7 nTPM
  • memory B-cell: 2.5 nTPM
  • naive B-cell: 2.4 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • myeloid DC: 2.2 nTPM

Brain region

  • choroid plexus: 97 nTPM
  • medulla oblongata: 91 nTPM
  • thalamus: 85 nTPM
  • midbrain: 79 nTPM
  • cerebral cortex: 77 nTPM
  • pons: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.09
gnomAD missense Z
2.43
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REPIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REPIN1 as an antibody target. Whether an autoantibody or antibody against REPIN1 could matter depends on whether native REPIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REPIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REPIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/REPIN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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