RENBP

Protein identityUniProt · HPA

UniProt accession

P51606

Gene

RENBP

Ensembl

ENSG00000102032

Chromosome

X

Canonical length

427 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

427 residues, UniProt reviewed canonical sequence.

>P51606|RENBP
     1  MSKGLPARQD MEKERETLQA WKERVGQELD RVVAFWMEHS HDQEHGGFFT CLGREGRVYD
    61  DLKYVWLQGR QVWMYCRLYR TFERFRHAQL LDAAKAGGEF LLRYARVAPP GKKCAFVLTR
   121  DGRPVKVQRT IFSECFYTMA MNELWRATGE VRYQTEAVEM MDQIVHWVQE DASGLGRPQL
   181  QGAPAAEPMA VPMMLLNLVE QLGEADEELA GKYAELGDWC ARRILQHVQR DGQAVLENVS
   241  EGGKELPGCL GRQQNPGHTL EAGWFLLRHC IRKGDPELRA HVIDKFLLLP FHSGWDPDHG
   301  GLFYFQDADN FCPTQLEWAM KLWWPHSEAM IAFLMGYSDS GDPVLLRLFY QVAEYTFRQF
   361  RDPEYGEWFG YLSREGKVAL SIKGGPFKGC FHVPRCLAMC EEMLGALLSR PAPAPSPAPT
   421  PACRGAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RENBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

68 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.49

gnomAD pLI

0.45

gnomAD missense Z

0.79

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate metabolic process
• N-acetylglucosamine metabolic process
• N-acetylmannosamine metabolic process
• N-acetylneuraminate catabolic process
• regulation of blood pressure

Molecular functions

• endopeptidase inhibitor activity
• identical protein binding
• peptidase inhibitor activity
• N-acylglucosamine 2-epimerase activity

Cellular components

• cytosol
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• Six-hairpin glycosidase superfamily
• Six-hairpin glycosidase-like superfamily
• N-acylglucosamine 2-epimerase/Cellobiose 2-epimerase
• AGE domain
• N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)

KeywordsUniProt

• Alternative initiation
• Isomerase