Seroatlas · Human Serome Atlas

REELD1

Reelin domain-containing protein 1

Also known as: RELD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GV85
Gene: REELD1
Ensembl: ENSG00000250673
Chromosome: 4
Canonical length: 526 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>A0A1B0GV85|REELD1
     1  MRMQAALVGW ACTTLCLASC SSAFSHGAST VACDDMQPKH IQAQPQHQDS HHITIHTHRT
    61  SYAPGDKIPV TVRSSRDFMG FLLQARRVSD HQIAGTFVLI PPHSKLMTCF QEADAVTHSD
   121  KSLKRNLSFV WKAPAQPVGD IKFLLSVVQS YFVYWARIES SVVSQQTHSS AHSDDRMEPR
   181  LLMPNLHQRL GDVEGAAPAP RTPITLPQQH THVFAVALPG AAEEDNLDPV PASIWVTKFP
   241  GDAETLSQPS SHTATEGSIN QQPSGDSNPT LEPSLEVHRL ERLVALKRVS SESFASSLST
   301  HHRTQDDPSF DSLETCLSSD GGEQDKTKAS NRTVTQPPLS TVQLTYPQCL WSSETFTGNG
   361  VRASNPIPVL QTSGTSGLPA AGDQSEASRA SASFLPQSKH KELRAGKGNG EGGVGYPRQT
   421  NPRPDIGLEG AQAPLGIQLR TPQLGILLCL SATLGMALAA GLRYLHTQYC HQQTEVSFSE
   481  PASDAVARSN SGETVHVRKI GENSFVLVQA EYNWITPSVG SKKTVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REELD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

spleen: 1.3 nTPM
spinal cord: 1 nTPM
adipose tissue: 0.7 nTPM
basal ganglia: 0.7 nTPM
breast: 0.7 nTPM
kidney: 0.7 nTPM

Single-cell type

bergmann glia: 5 nCPM
respiratory deuterosomal cells: 3.1 nCPM
adipocytes: 1.9 nCPM
prostatic glandular cells: 1.9 nCPM
proximal tubule cells: 1.9 nCPM
myonuclei: 1.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.5 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REELD1 as an antibody target. Whether an autoantibody or antibody against REELD1 could matter depends on whether native REELD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REELD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REELD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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