Seroatlas · Human Serome Atlas

RD3L

Protein RD3-like

Also known as: RD3L_HUMAN, TDRD9-AS1, TDRD9AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DJH9
Gene
RD3L
Ensembl
ENSG00000227729
Chromosome
14
Canonical length
198 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RD3L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>P0DJH9|RD3L
     1  MPLFGWMKWP KNDSYKPTHY PGSDIVTKTL LRELKWHLKE RERLIQEIEN EQKVKKTGVD
    61  YNWLRNYQNP HTTIPVTEQR QLEVLCSQVQ PCQTGTILSR FREVLAENDV LPWEIVYIFK
   121  QVLKDFLSSS DRGSEQEDLE DSGSMDCSAP SVIQGDSSKR ADKDEIPTIS SYVDKNTKDR
   181  FPVFSHRIWN LPYYHPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RD3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 22 nTPM
  • retina: 12 nTPM
  • liver: 0.5 nTPM
  • urinary bladder: 0.4 nTPM
  • choroid plexus: 0.2 nTPM
  • parathyroid gland: 0.2 nTPM

Single-cell type

  • retinal amacrine cells: 74 nCPM
  • retinal bipolar cells: 65 nCPM
  • cone photoreceptor cells: 29 nCPM
  • retinal horizontal cells: 22 nCPM
  • platelets: 20 nCPM
  • retinal pigment epithelial cells: 13 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.5 nTPM
  • midbrain: 0.3 nTPM
  • thalamus: 0.3 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0.05
gnomAD missense Z
0.98
DepMap mean gene effect
0.15
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RD3L as an antibody target. Whether an autoantibody or antibody against RD3L could matter depends on whether native RD3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RD3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RD3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RD3L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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