Seroatlas · Human Serome Atlas

RCN3

Reticulocalbin-3

Also known as: RCN3_HUMAN, RLP49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96D15
Gene: RCN3
Ensembl: ENSG00000142552
Chromosome: 19
Canonical length: 328 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables calcium ion binding activity. Involved in several processes, including collagen biosynthetic process; positive regulation of peptidase activity; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q96D15|RCN3
     1  MMWRPSVLLL LLLLRHGAQG KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG NFQYDHEAFL
    61  GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA ELRAWIAHTQ QRHIRDSVSA
   121  AWDTYDTDRD GRVGWEELRN ATYGHYAPGE EFHDVEDAET YKKMLARDER RFRVADQDGD
   181  SMATREELTA FLHPEEFPHM RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA
   241  WVQTERQQFR DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA
   301  EILGNWNMFV GSQATNYGED LTRHHDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 123 nTPM
cervix: 73 nTPM
adipose tissue: 64 nTPM
spleen: 64 nTPM
liver: 62 nTPM
heart muscle: 55 nTPM

Single-cell type

hepatic stellate cells: 252 nCPM
decidual stromal cells: 108 nCPM
fibroblasts: 81 nCPM
oocytes: 55 nCPM
endometrial stromal cells: 46 nCPM
hofbauer cells: 45 nCPM

Immune cell

naive CD4 T-cell: 6.9 nTPM
neutrophil: 2.6 nTPM
naive CD8 T-cell: 2.3 nTPM
NK-cell: 1.8 nTPM
memory CD4 T-cell: 1.7 nTPM
eosinophil: 1.6 nTPM

Brain region

thalamus: 30 nTPM
choroid plexus: 27 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 17 nTPM
pons: 17 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCN3 as an antibody target. Whether an autoantibody or antibody against RCN3 could matter depends on whether native RCN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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