Seroatlas · Human Serome Atlas

RCN1

Reticulocalbin-1

Also known as: FLJ37041, PIG20, Rcal, RCN, RCN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15293
Gene
RCN1
Ensembl
ENSG00000049449
Chromosome
11
Canonical length
331 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q15293|RCN1
     1  MARGGRGRRL GLALGLLLAL VLAPRVLRAK PTVRKERVVR PDSELGERPP EDNQSFQYDH
    61  EAFLGKEDSK TFDQLTPDES KERLGKIVDR IDNDGDGFVT TEELKTWIKR VQKRYIFDNV
   121  AKVWKDYDRD KDDKISWEEY KQATYGYYLG NPAEFHDSSD HHTFKKMLPR DERRFKAADL
   181  NGDLTATREE FTAFLHPEEF EHMKEIVVLE TLEDIDKNGD GFVDQDEYIA DMFSHEENGP
   241  EPDWVLSERE QFNEFRDLNK DGKLDKDEIR HWILPQDYDH AQAEARHLVY ESDKNKDEKL
   301  TKEEILENWN MFVGSQATNY GEDLTKNHDE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
623 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 623 nTPM
  • placenta: 121 nTPM
  • ovary: 119 nTPM
  • urinary bladder: 106 nTPM
  • liver: 94 nTPM
  • blood vessel: 90 nTPM

Single-cell type

  • epididymal principal cells: 1,325 nCPM
  • epididymal efferent duct absorptive cells: 314 nCPM
  • decidual stromal cells: 284 nCPM
  • extravillous trophoblasts: 282 nCPM
  • migrating cytotrophoblasts: 249 nCPM
  • müller glia: 242 nCPM

Immune cell

  • intermediate monocyte: 16 nTPM
  • myeloid DC: 15 nTPM
  • gdT-cell: 15 nTPM
  • classical monocyte: 14 nTPM
  • memory CD8 T-cell: 12 nTPM
  • MAIT T-cell: 12 nTPM

Brain region

  • basal ganglia: 61 nTPM
  • hypothalamus: 58 nTPM
  • choroid plexus: 57 nTPM
  • spinal cord: 45 nTPM
  • white matter: 43 nTPM
  • medulla oblongata: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RCN1.

Disease | ImmuneIEDB

Conditions an epitope on RCN1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCN1 as an antibody target. Whether an autoantibody or antibody against RCN1 could matter depends on whether native RCN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...