RCL1

Protein identityUniProt · HPA

UniProt accession

Q9Y2P8

Gene

RCL1

Ensembl

ENSG00000120158

Chromosome

9

Canonical length

373 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable RNA endonuclease activity. Involved in ribosomal small subunit biogenesis. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q9Y2P8|RCL1
     1  MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRKIRARDD NPGLRDFEAS FIRLLDKITN
    61  GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE SLLCLAPFMK HPLKIVLRGV
   121  TNDQVDPSVD VLKATALPLL KQFGIDGESF ELKIVRRGMP PGGGGEVVFS CPVRKVLKPI
   181  QLTDPGKIKR IRGMAYSVRV SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVNSGKSPG
   241  FGLSLVAETT SGTFLSAELA SNPQGQGAAV LPEDLGRNCA RLLLEEIYRG GCVDSTNQSL
   301  ALLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQIMFK IETKPCGEEL KGGDKVLMTC
   361  VGIGFSNLSK TLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

229 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RCL1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 80 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Psychotic disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.57

gnomAD pLI

0.06

gnomAD missense Z

-1.05

DepMap mean gene effect

-1.16

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• ribosomal small subunit biogenesis

Molecular functions

• RNA endonuclease activity

Cellular components

• nucleolus
• nucleoplasm
• small-subunit processome

Protein domainsUniProt · Pfam · InterPro

• RNA 3'-terminal phosphate cyclase
• RNA 3'-terminal phosphate cyclase, insert domain
• RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
• RNA 3'-terminal phosphate cyclase-like, conserved site
• RNA 3'-terminal phosphate cyclase domain
• RNA 3'-terminal phosphate cyclase, insert domain superfamily
• RNA 3'-terminal phosphate cyclase domain superfamily
• RNA 3'-terminal phosphate cyclase
• RNA 3'-terminal phosphate cyclase (RTC), insert domain
• RNA 3'-terminal phosphate cyclase type 2

KeywordsUniProt

• Nucleus
• Ribosome biogenesis

InteractionsUniProt · HPA

Protein binding partners of RCL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BMS1