Seroatlas · Human Serome Atlas

RCE1

CAAX prenyl protease 2

Also known as: FACE-2, FACE2, FACE2_HUMAN, hRCE1, RCE1A, RCE1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y256
Gene: RCE1
Ensembl: ENSG00000173653
Chromosome: 11
Canonical length: 329 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9Y256|RCE1
     1  MAALGGDGLR LLSVSRPERP PESAALGGLG PGLCCWVSVF SCLSLACSYV GSLYVWKSEL
    61  PRDHPAVIKR RFTSVLVVSS LSPLCVLLWR ELTGIQPGTS LLTLMGFRLE GIFPAALLPL
   121  LLTMILFLGP LMQLSMDCPC DLADGLKVVL APRSWARCLT DMRWLRNQVI APLTEELVFR
   181  ACMLPMLAPC MGLGPAVFTC PLFFGVAHFH HIIEQLRFRQ SSVGNIFLSA AFQFSYTAVF
   241  GAYTAFLFIR TGHLIGPVLC HSFCNYMGFP AVCAALEHPQ RRPLLAGYAL GVGLFLLLLQ
   301  PLTDPKLYGS LPLCVLLERA GDSEAPLCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 32 nTPM
kidney: 23 nTPM
esophagus: 21 nTPM
bone marrow: 20 nTPM
skin: 19 nTPM
pancreas: 16 nTPM

Single-cell type

extravillous trophoblasts: 81 nCPM
migrating cytotrophoblasts: 66 nCPM
syncytiotrophoblasts: 66 nCPM
cytotrophoblasts: 62 nCPM
esophageal apical cells: 53 nCPM
decidual stromal cells: 30 nCPM

Immune cell

plasmacytoid DC: 29 nTPM
intermediate monocyte: 24 nTPM
basophil: 23 nTPM
memory CD8 T-cell: 22 nTPM
non-classical monocyte: 22 nTPM
classical monocyte: 21 nTPM

Brain region

cerebellum: 16 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 11 nTPM
basal ganglia: 10 nTPM
white matter: 9.5 nTPM
amygdala: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.16
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain
CAAX prenyl protease 2, eukaryotes
Type II CAAX prenyl endopeptidase Rce1-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCE1 as an antibody target. Whether an autoantibody or antibody against RCE1 could matter depends on whether native RCE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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