Seroatlas · Human Serome Atlas

RBM12B-AS1

Putative uncharacterized protein encoded by RBM12B-AS1

Also known as: RBAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P1G2
Gene
RBM12B-AS1
Canonical length
102 aa

OverviewNCBI Gene

No narrative summary is available for RBM12B-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>Q9P1G2|RBM12B-AS1
     1  MAQDFSQHPQ TGIIRRHRFY SPKPLSTTPR GQSFLLSRQA KVATWDPMLS PDFQPKSAFK
    61  LTWTAQPPCL SVTPSQGQTF HPNSPEGELP PDLTENTCPS QA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM12B-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0.02
gnomAD missense Z
1.09

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM12B-AS1 as an antibody target. Whether an autoantibody or antibody against RBM12B-AS1 could matter depends on whether native RBM12B-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM12B-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM12B-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM12B-AS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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