Seroatlas · Human Serome Atlas

RBKS

Ribokinase

Also known as: DKFZp686G13268, RBSK, RBSK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H477
Gene: RBKS
Ensembl: ENSG00000171174
Chromosome: 2
Canonical length: 322 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q9H477|RBKS
     1  MAASGEPQRQ WQEEVAAVVV VGSCMTDLVS LTSRLPKTGE TIHGHKFFIG FGGKGANQCV
    61  QAARLGAMTS MVCKVGKDSF GNDYIENLKQ NDISTEFTYQ TKDAATGTAS IIVNNEGQNI
   121  IVIVAGANLL LNTEDLRAAA NVISRAKVMV CQLEITPATS LEALTMARRS GVKTLFNPAP
   181  AIADLDPQFY TLSDVFCCNE SEAEILTGLT VGSAADAGEA ALVLLKRGCQ VVIITLGAEG
   241  CVVLSQTEPE PKHIPTEKVK AVDTTGAGDS FVGALAFYLA YYPNLSLEDM LNRSNFIAAV
   301  SVQAAGTQSS YPYKKDLPLT LF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBKS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

liver: 43 nTPM
adrenal gland: 28 nTPM
kidney: 26 nTPM
small intestine: 24 nTPM
duodenum: 24 nTPM
fallopian tube: 15 nTPM

Single-cell type

monocytes: 227 nCPM
mast cells: 212 nCPM
neutrophils: 212 nCPM
adrenal cortex cells: 171 nCPM
epicardial cells: 166 nCPM
vascular smooth muscle cells: 162 nCPM

Immune cell

memory CD8 T-cell: 4.8 nTPM
NK-cell: 4.5 nTPM
memory B-cell: 4.4 nTPM
MAIT T-cell: 4.2 nTPM
T-reg: 4.2 nTPM
naive B-cell: 3.7 nTPM

Brain region

cerebellum: 6 nTPM
choroid plexus: 5.9 nTPM
midbrain: 5 nTPM
medulla oblongata: 4.7 nTPM
hypothalamus: 4.4 nTPM
white matter: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Carbohydrate/purine kinase, PfkB, conserved site
Carbohydrate kinase PfkB
Ribokinase-like
pfkB family carbohydrate kinase
Ribokinase/fructokinase
Ribokinase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBKS as an antibody target. Whether an autoantibody or antibody against RBKS could matter depends on whether native RBKS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBKS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBKS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...