Seroatlas · Human Serome Atlas

RBIS

Ribosomal biogenesis factor

Also known as: C8orf59, RBIS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N0T1
Gene
RBIS
Ensembl
ENSG00000176731
Chromosome
8
Canonical length
100 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Involved in ribosome biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q8N0T1|RBIS
     1  MAKNKLRGPK SRNVFHIASQ KNFKAKNKAK PVTTNLKKIN IMNEEKVNRV NKAFVNVQKE
    61  LAHFAKSISL EPLQKELIPQ QRHESKPVNV DEATRLMALL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBIS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 98 nTPM
  • heart muscle: 96 nTPM
  • stomach: 94 nTPM
  • breast: 89 nTPM
  • ovary: 88 nTPM
  • esophagus: 86 nTPM

Single-cell type

  • esophageal suprabasal cells: 330 nCPM
  • megakaryocytes: 328 nCPM
  • esophageal apical cells: 277 nCPM
  • esophageal basal cells: 243 nCPM
  • ovarian stromal cells: 232 nCPM
  • gastric chief cells: 226 nCPM

Immune cell

  • plasmacytoid DC: 119 nTPM
  • NK-cell: 105 nTPM
  • myeloid DC: 97 nTPM
  • naive CD4 T-cell: 96 nTPM
  • naive CD8 T-cell: 95 nTPM
  • T-reg: 91 nTPM

Brain region

  • white matter: 31 nTPM
  • spinal cord: 29 nTPM
  • hypothalamus: 28 nTPM
  • cerebellum: 26 nTPM
  • medulla oblongata: 26 nTPM
  • choroid plexus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0.01
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribosomal biogenesis factor
  • Domain of unknown function (DUF4665)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBIS as an antibody target. Whether an autoantibody or antibody against RBIS could matter depends on whether native RBIS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBIS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBIS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBIS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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