Seroatlas · Human Serome Atlas

RBBP9

Serine hydrolase RBBP9

Also known as: Bog, RBBP9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75884
Gene: RBBP9
Ensembl: ENSG00000089050
Chromosome: 20
Canonical length: 186 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>O75884|RBBP9
     1  MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME
    61  TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW
   121  EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS
   181  LLKVPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBBP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

liver: 24 nTPM
thyroid gland: 22 nTPM
kidney: 16 nTPM
parathyroid gland: 15 nTPM
cervix: 13 nTPM
skin: 10 nTPM

Single-cell type

respiratory deuterosomal cells: 38 nCPM
respiratory secretory cells: 35 nCPM
conjunctival goblet cells: 27 nCPM
retinal pigment epithelial cells: 26 nCPM
respiratory basal cells: 23 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

basophil: 9.3 nTPM
T-reg: 3 nTPM
MAIT T-cell: 2.9 nTPM
intermediate monocyte: 2.5 nTPM
memory CD4 T-cell: 2.3 nTPM
memory B-cell: 2.2 nTPM

Brain region

choroid plexus: 16 nTPM
thalamus: 12 nTPM
white matter: 12 nTPM
cerebellum: 12 nTPM
midbrain: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.05
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine hydrolase activity

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Alpha/Beta hydrolase fold
Serine hydrolase RBBP9/YdeN
Serine hydrolase

KeywordsUniProt

Hydrolase

InteractionsUniProt · HPA

Protein binding partners of RBBP9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBBP9 as an antibody target. Whether an autoantibody or antibody against RBBP9 could matter depends on whether native RBBP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBBP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBBP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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