Seroatlas · Human Serome Atlas

RBBP8NL

RBBP8 N-terminal-like protein

Also known as: C20orf151, dJ908M14.3, RB8NL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC74
Gene: RBBP8NL
Ensembl: ENSG00000130701
Chromosome: 20
Canonical length: 664 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

664 residues, UniProt reviewed canonical sequence.

>Q8NC74|RBBP8NL
     1  MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL REQQKTLKEN
    61  LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR IFILTNEMNG LKEENETLKE
   121  EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP SPGGWKAITE KPPGGHEEAE EDHQGVGLRG
   181  EEKPAGHRTS PVAKISPGAT LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN
   241  GTPPPLPARS SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL
   301  QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR LEGALHLLLA
   361  QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE GTRAALAAAG LSGGRHTQPA
   421  GPGRAQRTEA AATQDCALDK PLDLSEWGRA RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ
   481  SGPLTRSPQA LSNGTKGTRV PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP
   541  PHPQPPPHPQ PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP
   601  ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE DHSPSPNSSP
   661  WEET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBBP8NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

esophagus: 8.7 nTPM
skin: 4.5 nTPM
small intestine: 4.4 nTPM
duodenum: 4.2 nTPM
salivary gland: 4.1 nTPM
prostate: 3.6 nTPM

Single-cell type

enterocytes: 144 nCPM
goblet cells: 58 nCPM
colonocytes: 56 nCPM
neuroendocrine cells: 35 nCPM
esophageal apical cells: 30 nCPM
enteric stem cells: 27 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.8 nTPM
medulla oblongata: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.01
gnomAD missense Z: 0.43
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBBP8NL as an antibody target. Whether an autoantibody or antibody against RBBP8NL could matter depends on whether native RBBP8NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBBP8NL is annotated as secreted, so native RBBP8NL circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RBBP8NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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