Seroatlas · Human Serome Atlas

RASSF10

Ras association domain-containing protein 10

Also known as: RASFA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NK89
Gene: RASSF10
Ensembl: ENSG00000189431
Chromosome: 11
Canonical length: 507 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Predicted to be located in centrosome; cytosol; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>A6NK89|RASSF10
     1  MDPSEKKISV WICQEEKLVS GLSRRTTCSD VVRVLLEDGC RRRRRQRRSR RLGSAGDPHG
    61  PGELPEPPNE DDEDDDEALP QGMLCGPPQC YCIVEKWRGF ERILPNKTRI LRLWAAWGEE
   121  QENVRFVLVR SEASLPNAGP RSAEARVVLS RERPCPARGA PARPSLAMTQ EKQRRVVRKA
   181  FRKLAKLNRR RQQQTPSSCS STSSSTASSC SSSPRTHESA SVERMETLVH LVLSQDHTIR
   241  QQVQRLHELD REIDHYEAKV HLDRMRRHGV NYVQDTYLVG AGIELDGSRP GEEPEEVAAE
   301  AEEAAAAPPL AGEAQAAALE ELARRCDDLL RLQEQRVQQE ELLERLSAEI QEELNQRWMR
   361  RRQEELAARE EPLEPDGGPD GELLLEQERV RTQLSTSLYI GLRLNTDLEA VKSDLDYSQQ
   421  QWDSKKRELQ GLLQTLHTLE LTVAPDGAPG SGSPSREPGP QACADMWVDQ ARGLAKSGPG
   481  NDEDSDTGLS SMHSQDSDSL PMCESLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

skin: 6.4 nTPM
esophagus: 5.7 nTPM
salivary gland: 4.3 nTPM
stomach: 3.4 nTPM
fallopian tube: 2.8 nTPM
kidney: 2.6 nTPM

Single-cell type

esophageal basal cells: 33 nCPM
esophageal apical cells: 22 nCPM
esophageal suprabasal cells: 21 nCPM
epididymal basal cells: 13 nCPM
endometrial glandular cells: 13 nCPM
respiratory ciliated cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 2.7 nTPM
midbrain: 2.4 nTPM
basal ganglia: 2.2 nTPM
medulla oblongata: 2 nTPM
white matter: 1.5 nTPM
cerebral cortex: 1.4 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ras-associating domain
Ubiquitin-like domain superfamily
N-terminal RASSF family
Ras association domain-containing protein 8/10, RA domain
Ras association domain-containing protein 8/10, RA domain
Ras association domain-containing protein 10, RA domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF10 as an antibody target. Whether an autoantibody or antibody against RASSF10 could matter depends on whether native RASSF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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