Seroatlas · Human Serome Atlas

RASGEF1C

Ras-GEF domain-containing family member 1C

Also known as: FLJ35841, RGF1C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N431
Gene: RASGEF1C
Ensembl: ENSG00000146090
Chromosome: 5
Canonical length: 466 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q8N431|RASGEF1C
     1  MPQTLSASDM VTPGSLSPPP TEPTDGEQAG QPLLDGAPSS ASLETLIQHL VPTADYYPEK
    61  AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK ARVRKFGPKL LQLLAEWTET
   121  FPRDFQEEST IGHLKDVVGR IAPCDEAYRK RMHQLLQALH QKLAALRQGP EGLVGADKPI
   181  SYRTKPPASI HRELLGVCSD PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLASTKPC
   241  FSDKTSNLEA YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA
   301  IISGMNMSPV SRLKKTWAKV RTAKFFILEH QMDPTGNFCN YRTALRGAAH RSLTAHSSRE
   361  KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK QVGEFITWKQ VECPFEQDAS
   421  ITHYLYTAPI FSEDGLYLAS YESESPENQT EKERWKALRS SILGKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASGEF1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 32 nTPM
spinal cord: 10 nTPM
cerebral cortex: 9.1 nTPM
amygdala: 6 nTPM
testis: 5.3 nTPM
midbrain: 5.1 nTPM

Single-cell type

microglia: 689 nCPM
schwann cells: 96 nCPM
brain excitatory neurons: 67 nCPM
retinal ganglion cells: 46 nCPM
retinal bipolar cells: 46 nCPM
late primary spermatocytes: 45 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 49 nTPM
cerebral cortex: 37 nTPM
pons: 19 nTPM
medulla oblongata: 18 nTPM
white matter: 18 nTPM
basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 1.7
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Guanine-nucleotide releasing factor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASGEF1C as an antibody target. Whether an autoantibody or antibody against RASGEF1C could matter depends on whether native RASGEF1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASGEF1C is annotated at the cell surface, where native RASGEF1C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RASGEF1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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