Seroatlas · Human Serome Atlas

RASGEF1A

Ras-GEF domain-containing family member 1A

Also known as: CG4853, FLJ37817, RGF1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9B8
Gene: RASGEF1A
Ensembl: ENSG00000198915
Chromosome: 10
Canonical length: 481 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Involved in cell migration and positive regulation of Ras protein signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q8N9B8|RASGEF1A
     1  MPQTSVVFSS ILGPSCSGQV QPGMGERGGG AGGGSGDLIF QDGHLISGSL EALMEHLVPT
    61  VDYYPDRTYI FTFLLSSRVF MPPHDLLARV GQICVEQKQQ LEAGPEKAKL KSFSAKIVQL
   121  LKEWTEAFPY DFQDEKAMAE LKAITHRVTQ CDEENGTVKK AIAQMTQSLL LSLAARSQLQ
   181  ELREKLRPPA VDKGPILKTK PPAAQKDILG VCCDPLVLAQ QLTHIELDRV SSIYPEDLMQ
   241  IVSHMDSLDN HRCRGDLTKT YSLEAYDNWF NCLSMLVATE VCRVVKKKHR TRMLEFFIDV
   301  ARECFNIGNF NSMMAIISGM NLSPVARLKK TWSKVKTAKF DVLEHHMDPS SNFCNYRTAL
   361  QGATQRSQMA NSSREKIVIP VFNLFVKDIY FLHKIHTNHL PNGHINFKKF WEISRQIHEF
   421  MTWTQVECPF EKDKKIQSYL LTAPIYSEEA LFVASFESEG PENHMEKDSW KTLRTTLLNR
   481  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASGEF1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 19 nTPM
cerebral cortex: 19 nTPM
hippocampal formation: 16 nTPM
amygdala: 15 nTPM
cerebellum: 14 nTPM
bone marrow: 14 nTPM

Single-cell type

brain inhibitory neurons: 31 nCPM
brain excitatory neurons: 29 nCPM
other brain neurons: 27 nCPM
neutrophils: 24 nCPM
adrenal medulla cells: 21 nCPM
pituitary stem cells: 20 nCPM

Immune cell

neutrophil: 9.5 nTPM
NK-cell: 6.4 nTPM
eosinophil: 6.1 nTPM
plasmacytoid DC: 5.1 nTPM
gdT-cell: 2.9 nTPM
myeloid DC: 2.9 nTPM

Brain region

hippocampal formation: 35 nTPM
cerebral cortex: 35 nTPM
amygdala: 34 nTPM
hypothalamus: 34 nTPM
basal ganglia: 32 nTPM
white matter: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 2.66
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Guanine-nucleotide releasing factor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASGEF1A as an antibody target. Whether an autoantibody or antibody against RASGEF1A could matter depends on whether native RASGEF1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASGEF1A is annotated at the cell surface, where native RASGEF1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RASGEF1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...