Seroatlas · Human Serome Atlas

RARRES2

Retinoic acid receptor responder protein 2

Also known as: HP10433, RARR2_HUMAN, TIG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99969
Gene: RARRES2
Ensembl: ENSG00000106538
Chromosome: 7
Canonical length: 163 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q99969|RARRES2
     1  MRRLLIPLAL WLGAVGVGVA ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF
    61  PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE
   121  TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFSKAL PRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RARRES2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 2,646 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 2,646 nTPM
liver: 2,145 nTPM
choroid plexus: 1,531 nTPM
pancreas: 1,397 nTPM
ovary: 675 nTPM
parathyroid gland: 590 nTPM

Single-cell type

hepatocytes: 2,988 nCPM
salivary ionocytes: 1,360 nCPM
respiratory ionocytes: 889 nCPM
pancreatic acinar cells: 869 nCPM
epididymal clear cells: 835 nCPM
decidual stromal cells: 724 nCPM

Immune cell

plasmacytoid DC: 5.4 nTPM
NK-cell: 0.7 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 597 nTPM
midbrain: 75 nTPM
medulla oblongata: 58 nTPM
white matter: 57 nTPM
spinal cord: 56 nTPM
thalamus: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cystatin superfamily
Retinoic acid receptor responder protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RARRES2 as an antibody target. Whether an autoantibody or antibody against RARRES2 could matter depends on whether native RARRES2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RARRES2 is annotated as secreted, so native RARRES2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RARRES2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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