Seroatlas · Human Serome Atlas

RAPGEFL1

Rap guanine nucleotide exchange factor-like 1

Also known as: Link-GEFII, RPGFL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHV5
Gene
RAPGEFL1
Ensembl
ENSG00000108352
Chromosome
17
Canonical length
662 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>Q9UHV5|RAPGEFL1
     1  MKPLEKFLKK QTSQLAGRTV AGGPGGGLGS CGGPGGGGGP GGGGGPAGGQ RSLQRRQSVS
    61  RLLLPAFLRE PPAEPGLEPP VPEEGGEPAG VAEEPGSGGP CWLQLEEVPG PGPLGGGGPL
   121  RSPSSYSSDE LSPGEPLTSP PWAPLGAPER PEHLLNRVLE RLAGGATRDS AASDILLDDI
   181  VLTHSLFLPT EKFLQELHQY FVRAGGMEGP EGLGRKQACL AMLLHFLDTY QGLLQEEEGA
   241  GHIIKDLYLL IMKDESLYQG LREDTLRLHQ LVETVELKIP EENQPPSKQV KPLFRHFRRI
   301  DSCLQTRVAF RGSDEIFCRV YMPDHSYVTI RSRLSASVQD ILGSVTEKLQ YSEEPAGRED
   361  SLILVAVSSS GEKVLLQPTE DCVFTALGIN SHLFACTRDS YEALVPLPEE IQVSPGDTEI
   421  HRVEPEDVAN HLTAFHWELF RCVHELEFVD YVFHGERGRR ETANLELLLQ RCSEVTHWVA
   481  TEVLLCEAPG KRAQLLKKFI KIAALCKQNQ DLLSFYAVVM GLDNAAVSRL RLTWEKLPGK
   541  FKNLFRKFEN LTDPCRNHKS YREVISKMKP PVIPFVPLIL KDLTFLHEGS KTLVDGLVNI
   601  EKLHSVAEKV RTIRKYRSRP LCLDMEASPN HLQTKAYVRQ FQVIDNQNLL FELSYKLEAN
   661  SQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAPGEFL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
232 nTPM

Expression across tissuesHPA

Tissue

  • skin: 232 nTPM
  • esophagus: 195 nTPM
  • vagina: 110 nTPM
  • cervix: 75 nTPM
  • cerebral cortex: 60 nTPM
  • colon: 52 nTPM

Single-cell type

  • esophageal suprabasal cells: 254 nCPM
  • esophageal apical cells: 249 nCPM
  • prostatic hillock cells: 239 nCPM
  • suprabasal keratinocytes: 198 nCPM
  • ocular epithelial cells: 149 nCPM
  • respiratory basal cells: 122 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • gdT-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 138 nTPM
  • hippocampal formation: 131 nTPM
  • amygdala: 96 nTPM
  • basal ganglia: 89 nTPM
  • white matter: 78 nTPM
  • hypothalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.3
gnomAD missense Z
1.76
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAPGEFL1 as an antibody target. Whether an autoantibody or antibody against RAPGEFL1 could matter depends on whether native RAPGEFL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAPGEFL1 is annotated at the cell surface, where native RAPGEFL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAPGEFL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAPGEFL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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