Seroatlas · Human Serome Atlas

RANGRF

Ran guanine nucleotide release factor

Also known as: HSPC165, HSPC236, MOG1, MOG1_HUMAN, RANGNRF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HD47
Gene: RANGRF
Ensembl: ENSG00000108961
Chromosome: 17
Canonical length: 186 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q9HD47|RANGRF
     1  MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE LLELQAHVRG
    61  EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ EAWVLSGKQQ IAKENQQVAK
   121  DVTLHQALLR LPQYQTDLLL TFNQPPPDNR SSLGPENLSP APWSLGDFEQ LVTSLTLHDP
   181  NIFGPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANGRF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

testis: 87 nTPM
basal ganglia: 51 nTPM
kidney: 50 nTPM
heart muscle: 45 nTPM
cervix: 45 nTPM
stomach: 41 nTPM

Single-cell type

late spermatids: 2,172 nCPM
late primary spermatocytes: 460 nCPM
early spermatids: 408 nCPM
syncytiotrophoblasts: 139 nCPM
cytotrophoblasts: 116 nCPM
epididymal efferent duct absorptive cells: 81 nCPM

Immune cell

T-reg: 130 nTPM
memory CD4 T-cell: 83 nTPM
naive B-cell: 82 nTPM
eosinophil: 82 nTPM
memory CD8 T-cell: 78 nTPM
memory B-cell: 75 nTPM

Brain region

thalamus: 23 nTPM
hypothalamus: 22 nTPM
basal ganglia: 21 nTPM
spinal cord: 19 nTPM
midbrain: 19 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ran-interacting Mog1 protein
Mog1/PsbP, alpha/beta/alpha sandwich
Ran-interacting Mog1 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANGRF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAN
RAN-GDP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANGRF as an antibody target. Whether an autoantibody or antibody against RANGRF could matter depends on whether native RANGRF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANGRF is annotated at the cell surface, where native RANGRF is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RANGRF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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