Seroatlas · Human Serome Atlas

RANBP3L

Ran-binding protein 3-like

Also known as: FLJ25422, RNB3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VV4
Gene: RANBP3L
Ensembl: ENSG00000164188
Chromosome: 5
Canonical length: 465 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables SMAD binding activity. Predicted to be involved in several processes, including mesenchymal cell differentiation involved in bone development; negative regulation of osteoblast differentiation; and protein export from nucleus. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q86VV4|RANBP3L
     1  MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK RPAEDTLYEA
    61  AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA LVQSSVDIKS AEQGPVKHSK
   121  HVIRPAILQL PQARSCAKVR KTFGHKALES CKTKEKTNNK ISEGNSYLLS ENLSRARISV
   181  QLSTNQDFLG ATSVGCQPNE DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK
   241  EKPFKSIPKF PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL
   301  KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR LILNSKLWAQ
   361  MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA AIHHRLVALQ SFNKQRDVNQ
   421  AESLSETAQQ LNCESCDENE DDFIQVTKNG SDPSSWTHRQ SVACS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANBP3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 27 nTPM
kidney: 26 nTPM
amygdala: 25 nTPM
cerebral cortex: 25 nTPM
hippocampal formation: 15 nTPM
prostate: 13 nTPM

Single-cell type

astrocytes: 559 nCPM
pituitary stem cells: 368 nCPM
loop of henle epithelial cells: 358 nCPM
distal convoluted tubule cells: 230 nCPM
sertoli cells: 143 nCPM
smooth muscle cells: 116 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 70 nTPM
basal ganglia: 66 nTPM
hippocampal formation: 62 nTPM
amygdala: 62 nTPM
midbrain: 49 nTPM
thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SMAD binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANBP3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANBP3L as an antibody target. Whether an autoantibody or antibody against RANBP3L could matter depends on whether native RANBP3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANBP3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RANBP3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...