RANBP17

Protein identityUniProt · HPA

UniProt accession

Q9H2T7

Gene

RANBP17

Ensembl

ENSG00000204764

Chromosome

5

Canonical length

1088 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Nuclear membrane,Nuclear bodies,Cytosol

OverviewNCBI Gene

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

1088 residues, UniProt reviewed canonical sequence.

>Q9H2T7|RANBP17
     1  MALHFQSLAE LEVLCTHLYI GTDLTQRIEA EKALLELIDS PECLSKCQLL LEQGTTSYAQ
    61  LLAATCLSKL VSRVSPLPVE QRMDIRNYIL NYVASQPKLA PFVIQALIQV IAKITKLGWF
   121  EVQKDQFVFR EIIADVKKFL QGTVEHCIIG VIILSELTQE MNLVDYSRPS AKHRKIATSF
   181  RDTSLKDVLV LACSLLKEVF AKPLNLQDQC QQNLVMQVLK LVLNCLNFDF IGSSADESAD
   241  DLCTVQIPTT WRTIFLEPET LDLFFNLYHS LPPLLSQLAL SCLVQFASTR RSLFNSPERA
   301  KYLGNLIKGV KRILENPQGL SDPGNYHEFC RFLARLKTNY QLGELVMVKE YPEVIRLIAN
   361  FTITSLQHWE FAPNSVHYLL TLWQRMVASV PFVKSTEPHL LDTYAPEITK AFITSRLDSV
   421  AIVVRDHLDD PLDDTATVFQ QLEQLCTVSR CEYEKTCALL VQLFDQNAQN YQKLLHPYSG
   481  VTVDITIQEG RLAWLVYLVG TVVGGRLTYT STDEHDAMDG ELSCRVFQLI SLMDTGLPRC
   541  CNEKIELAIL WFLDQFRKTY VGDQLQRTSK VYARMSEVLG ITDDNHVLET FMTKIVTNLK
   601  YWGRYEPVIS RTLQFLNDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL GISDNHSLSD
   661  FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVAFETV LQIFNNNFKQ EDVKRMLIGL
   721  ARDLRGIAFA LNTKTSYTML FDWMYPTYLP LLQNAVERWY GEPTCTTPIL KLMAELMQNR
   781  SQRLNFDVSS PNGILLFREA SKMVCTYGNQ ILSLGSLSKD QIYPMKLKGI SICYSALKSA
   841  LCGNYVSFGV FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
   901  SFIINLEPPV LMYVLTSISE GLTTLDTVVS SSCCTSLDYI VTYLFKHIAK EGKKPLRCRE
   961  ATQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS VSRPLLGLIL LNEKYFSELR
  1021  ASLINSQPLP KQEVLAQCFR NLMEGVEQNL SVKNRDRFTQ NLSVFRRDVA EALRSDGNTE
  1081  PCSLDMMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANBP17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

1.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.32

gnomAD pLI

0

gnomAD missense Z

-1.11

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mRNA transport
• protein export from nucleus
• protein import into nucleus

Molecular functions

• GTP binding
• nuclear export signal receptor activity
• small GTPase binding

Cellular components

• cytoplasm
• nuclear pore

Protein domainsUniProt · Pfam · InterPro

• Importin-beta, N-terminal domain
• Armadillo-like helical
• Armadillo-type fold
• Exportin 4/7-like
• Exportin-7/Ran-binding protein 17, TPR domain
• Importin-beta N-terminal domain
• Exportin-7-like, TPR repeats

KeywordsUniProt

• Acetylation
• Cytoplasm
• mRNA transport
• Nuclear pore complex
• Nucleus
• Phosphoprotein
• Protein transport
• Translocation
• Transport