Seroatlas · Human Serome Atlas

RALGAPB

Ral GTPase-activating protein subunit beta

Also known as: DKFZp781M2411, KIAA1219, RalGAPbeta, RLGPB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X10
Gene: RALGAPB
Ensembl: ENSG00000170471
Chromosome: 20
Canonical length: 1494 aa
Protein class: Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables protein heterodimerization activity. Predicted to be involved in Ral protein signal transduction and activation of GTPase activity. Predicted to act upstream of or within regulation of exocyst localization and regulation of protein localization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1494 residues, UniProt reviewed canonical sequence.

>Q86X10|RALGAPB
     1  MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV AGSENLLKTD
    61  KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP KDSIPLPVIK EPNQYVQTIL
   121  KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK LARESSLMAR ETWEVLLLFL LQINDILLAP
   181  PTVQGGIAEN LAEKLIGVLF EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV
   241  ICALTSRLLR FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA
   301  IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL GISRPRSDSA
   361  PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST VSTAHASKVQ HQTSSTSPLS
   421  SPNQTSSEPR PLPAPRRPKV NSILNLFGSW LFDAAFVHCK LHNGINRDSS MTAITTQASM
   481  EFRRKGSQMS TDTMVSNPMF DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR
   541  FYMLLIQGLQ INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK
   601  FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD KPITFLSLKL
   661  RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG CQMEMGGGEN NLKSHSRTNS
   721  GISSASGGST EPTTPDSERP AQALLRDYAL NTDSAAGLLI RSIHLVTQRL NSQWRQDMSI
   781  SLAALELLSG LAKVKVMVDS GDRKRAISSV CTYIVYQCSR PAPLHSRDLH SMIVAAFQCL
   841  CVWLTEHPDM LDEKDCLKEV LEIVELGISG SKSKNNEQEV KYKGDKEPNP ASMRVKDAAE
   901  ATLTCIMQLL GAFPSPSGPA SPCSLVNETT LIKYSRLPTI NKHSFRYFVL DNSVILAMLE
   961  QPLGNEQNDF FPSVTVLVRG MSGRLAWAQQ LCLLPRGAKA NQKLFVPEPR PVPKNDVGFK
  1021  YSVKHRPFPE EVDKIPFVKA DLSIPDLHEI VTEELEERHE KLRSGMAQQI AYEIHLEQQS
  1081  EEELQKRSFP DPVTDCKPPP PAQEFQTARL FLSHFGFLSL EALKEPANSR LPPHLIALDS
  1141  TIPGFFDDIG YLDLLPCRPF DTVFIFYMKP GQKTNQEILK NVESSRTVQP HFLEFLLSLG
  1201  WSVDVGRHPG WTGHVSTSWS INCCDDGEGS QQEVISSEDI GASIFNGQKK VLYYADALTE
  1261  IAFVVPSPVE SLTDSLESNI SDQDSDSNMD LMPGILKQPS LTLELFPNHT DNLNSSQRLS
  1321  PSSRMRKLPQ GRPVPPLGPE TRVSVVWVER YDDIENFPLS ELMTEISTGV ETTANSSTSL
  1381  RSTTLEKEVP VIFIHPLNTG LFRIKIQGAT GKFNMVIPLV DGMIVSRRAL GFLVRQTVIN
  1441  ICRRKRLESD SYSPPHVRRK QKITDIVNKY RNKQLEPEFY TSLFQEVGLK NCSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALGAPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 23 nTPM
testis: 19 nTPM
retina: 17 nTPM
thyroid gland: 17 nTPM
thymus: 16 nTPM
breast: 15 nTPM

Single-cell type

somatotrophs: 175 nCPM
neutrophils: 161 nCPM
prostatic glandular cells: 149 nCPM
neutrophil progenitors: 147 nCPM
choroid plexus epithelial cells: 133 nCPM
gonadotrophs: 129 nCPM

Immune cell

eosinophil: 2.4 nTPM
NK-cell: 2 nTPM
memory CD4 T-cell: 1.7 nTPM
neutrophil: 1.7 nTPM
MAIT T-cell: 1.6 nTPM
memory CD8 T-cell: 1.5 nTPM

Brain region

choroid plexus: 45 nTPM
cerebellum: 42 nTPM
cerebral cortex: 35 nTPM
thalamus: 35 nTPM
hypothalamus: 34 nTPM
white matter: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RALGAPB.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 3.18
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Rap/Ran-GAP domain
Rap/Ran-GAP superfamily
Ral GTPase-activating protein subunit alpha/beta, N-terminal domain
RALGAPB N-terminal domain
Ral GTPase-activating protein subunit beta

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RALGAPB as an antibody target. Whether an autoantibody or antibody against RALGAPB could matter depends on whether native RALGAPB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RALGAPB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RALGAPB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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