Seroatlas · Human Serome Atlas

RALGAPA2

Ral GTPase-activating protein subunit alpha-2

Also known as: AS250, C20orf74, dJ1049G11.4, KIAA1272, RapGAPalpha2, RGPA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2PPJ7
Gene: RALGAPA2
Ensembl: ENSG00000188559
Chromosome: 20
Canonical length: 1873 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1873 residues, UniProt reviewed canonical sequence.

>Q2PPJ7|RALGAPA2
     1  MFSRRSHGDV KKSTQKVLDP KKDVLTRLKH LRALLDNVDA NDLKQFFETN YSQIYFIFYE
    61  NFIALENSLK LKGNNKSQRE ELDSILFLFE KILQFLPERI FFRWHYQSIG STLKKLLHTG
   121  NSIKIRCEGI RLFLLWLQAL QTNCAEEQVL IFACLVPGFP AVMSSRGPCT LETLINPSPS
   181  VADVKIYPEE ITPLLPAISG EKIAEDQTCF FLQILLKYMV IQAASLEWKN KENQDTGFKF
   241  LFTLFRKYYL PHLFPSFTKL TNIYKPVLDI PHLRPKPVYI TTTRDNENIY STKIPYMAAR
   301  VVFIKWIVTF FLEKKYLTAT QNTKNGVDVL PKIIQTVGGG AVQERAPELD GGGPTEQDKS
   361  HSNSSTLSDR RLSNSSLCSI EEEHRMVYEM VQRILLSTRG YVNFVNEVFH QAFLLPSCEI
   421  AVTRKVVQVY RKWILQDKPV FMEEPDRKDV AQEDAEKLGF SETDSKEASS ESSGHKRSSS
   481  WGRTYSFTSA MSRGCVTEEE NTNVKAGVQA LLQVFLTNSA NIFLLEPCAE VPVLLKEQVD
   541  ACKAVLIIFR RMIMELTMNK KTWEQMLQIL LRITEAVMQK PKDKQIKDLF AQSLAGLLFR
   601  TLMVAWIRAN LCVYISRELW DDFLGVLSSL TEWEELINEW ANIMDSLTAV LARTVYGVEM
   661  TNLPLDKLSE QKEKKQRGKG CVLDPQKGTT VGRSFSLSWR SHPDVTEPMR FRSATTSGAP
   721  GVEKARNIVR QKATEVEECQ QSENAPAAGS GHLTVGQQQQ VLRSSSTSDI PEPLCSDSSQ
   781  GQKAENTQNS SSSEPQPIQE NKGHVKREHE GITILVRRSS SPAELDLKDD LQQTQGKCRE
   841  RQKSESTNSD TTLGCTNEAE LSMGPWQTCE EDPELNTPTD VVADADARHW LQLSPTDASN
   901  LTDSSECLTD DCSIIAGGSL TGWHPDSAAV LWRRVLGILG DVNNIQSPKI HARVFCYLYE
   961  LWYKLAKIRD NLAISLDNQS SPSPPVLIPP LRMFASWLFK AATLPNEYKE GKLQAYRLIC
  1021  AMMTRRQDVL PNSDFLVHFY LVMHLGLTSE DQDILNTIIR HCPPRFFSLG FPGFSMLVGD
  1081  FITAAARVLS TDILTAPRSE AVTVLGSLVC FPNTYQEIPL LQSVPEVNEA ITGTEDVKHY
  1141  LINILLKNAT EEPNEYARCI AVCSLGVWIC EELAQCTSHP QVKEAINVIG VTLKFPNKIV
  1201  AQVACDVLQL LVSYWEKLQM FETSLPRKMA EILVATVAFL LPSAEYSSVE TDKKFIVSLL
  1261  LCLLDWCMAL PVSVLLHPVS TAVLEEQHSA RAPLLDYIYR VLHCCVCGSS TYTQQSHYIL
  1321  TLADLSSTDY DPFLPLANVK SSEPVQYHSS AELGNLLTVE EEKKRRSLEL IPLTARMVMA
  1381  HLVNHLGHYP LSGGPAILHS LVSENHDNAH VEGSELSFEV FRSPNLQLFV FNDSTLISYL
  1441  QTPTEGPVGG SPVGSLSDVR VIVRDISGKY SWDGKVLYGP LEGCLAPNGR NPSFLISSWH
  1501  RDTFGPQKDS SQVEEGDDVL DKLLENIGHT SPECLLPSQL NLNEPSLTPC GMNYDQEKEI
  1561  IEVILRQNAQ EDEYIQSHNF DSAMKVTSQG QPSPVEPRGP FYFCRLLLDD LGMNSWDRRK
  1621  NFHLLKKNSK LLRELKNLDS RQCRETHKIA VFYIAEGQED KCSILSNERG SQAYEDFVAG
  1681  LGWEVDLSTH CGFMGGLQRN GSTGQTAPYY ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL
  1741  GNDEVHIVWS EHSRDYRRGI IPTAFGDVSI IIYPMKNHMF FIAITKKPEV PFFGPLFDGA
  1801  IVSGKLLPSL VCATCINASR AVKCLIPLYQ SFYEERALYL EAIIQNHREV MTFEDFAAQV
  1861  FSPSPSYSLS GTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALGAPA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
liver: 24 nTPM
lung: 22 nTPM
tongue: 20 nTPM
bone marrow: 19 nTPM
thyroid gland: 18 nTPM

Single-cell type

neutrophils: 3,116 nCPM
myonuclei: 1,449 nCPM
neutrophil progenitors: 1,427 nCPM
vascular endothelial cells: 1,006 nCPM
lymphatic endothelial cells: 997 nCPM
endometrial luminal cells: 861 nCPM

Immune cell

neutrophil: 4.2 nTPM
eosinophil: 3.6 nTPM
basophil: 3 nTPM
NK-cell: 2.6 nTPM
MAIT T-cell: 1.2 nTPM
classical monocyte: 1.1 nTPM

Brain region

thalamus: 43 nTPM
cerebellum: 38 nTPM
white matter: 34 nTPM
midbrain: 33 nTPM
cerebral cortex: 32 nTPM
pons: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RALGAPA2 as an antibody target. Whether an autoantibody or antibody against RALGAPA2 could matter depends on whether native RALGAPA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RALGAPA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RALGAPA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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