Seroatlas · Human Serome Atlas

RAD21L1

Double-strand-break repair protein rad21-like protein 1

Also known as: dJ545L17.2, RAD21L, RD21L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H4I0
Gene
RAD21L1
Ensembl
ENSG00000244588
Chromosome
20
Canonical length
556 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Predicted to be located in chromosome and nucleus. Predicted to be part of meiotic cohesin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q9H4I0|RAD21L1
     1  MFYTHVLMSK RGPLAKIWLA AHWEKKLTKA HVFECNLEIT IEKILSPKVK IALRTSGHLL
    61  LGVVRIYNRK AKYLLADCSE AFLKMKMTFC PGLVDLPKEN FEASYNAITL PEEFHDFDTQ
   121  NMNAIDVSEH FTQNQSRPEE ITLRENFDND LIFQAESFGE ESEILRRHSF FDDNILLNSS
   181  GPLIEHSSGS LTGERSLFYD SGDGFGDEGA AGEMIDNLLQ DDQNILLEDM HLNREISLPS
   241  EPPNSLAVEP DNSECICVPE NEKMNETILL STEEEGFTLD PIDISDIAEK RKGKKRRLLI
   301  DPIKELSSKV IHKQLTSFAD TLMVLELAPP TQRLMMWKKR GGVHTLLSTA AQDLIHAELK
   361  MLFTKCFLSS GFKLGRKMIQ KESVREEVGN QNIVETSMMQ EPNYQQELSK PQTWKDVIGG
   421  SQHSSHEDTN KNINSEQDIV EMVSLAAEES SLMNDLFAQE IEYSPVELES LSNEENIETE
   481  RWNGRILQML NRLRESNKMG MQSFSLMKLC RNSDRKQAAA KFYSFLVLKK QLAIELSQSA
   541  PYADIIATMG PMFYNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD21L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • retina: 0.8 nTPM
  • seminal vesicle: 0.2 nTPM
  • lymph node: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • late spermatids: 202 nCPM
  • early spermatids: 184 nCPM
  • early primary spermatocytes: 104 nCPM
  • late primary spermatocytes: 59 nCPM
  • endometrial luminal cells: 9.2 nCPM
  • rod photoreceptor cells: 7.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.1 nTPM
  • hypothalamus: 1.1 nTPM
  • amygdala: 1 nTPM
  • midbrain: 1 nTPM
  • cerebellum: 0.9 nTPM
  • pons: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD21L1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 69 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
1.39
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD21L1 as an antibody target. Whether an autoantibody or antibody against RAD21L1 could matter depends on whether native RAD21L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD21L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD21L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAD21L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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