Seroatlas · Human Serome Atlas

R3HDML

Peptidase inhibitor R3HDML

Also known as: CRSPL_HUMAN, dJ881L22.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3Y0
Gene: R3HDML
Ensembl: ENSG00000101074
Chromosome: 20
Canonical length: 253 aa
Protein class: Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable peptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9H3Y0|R3HDML
     1  MPLLPSTVGL AGLLFWAGQA VNALIMPNAT PAPAQPESTA MRLLSGLEVP RYRRKRHISV
    61  RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW ATQCIWAHGP SQLMRYVGQN
   121  LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP RDCNPHCPWR CDGPTCSHYT QMVWASSNRL
   181  GCAIHTCSSI SVWGNTWHRA AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM
   241  CFKGLKSNKF TWF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against R3HDML can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

small intestine: 2.3 nTPM
duodenum: 2 nTPM
colon: 0.7 nTPM
stomach: 0.4 nTPM
testis: 0.4 nTPM
appendix: 0.3 nTPM

Single-cell type

enteric stem cells: 16 nCPM
paneth cells: 12 nCPM
tuft cells: 12 nCPM
enteric transient amplifying cells: 5.7 nCPM
enterocytes: 3.6 nCPM
colonocytes: 3.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.4 nTPM
white matter: 1.4 nTPM
thalamus: 1.3 nTPM
cerebellum: 1.1 nTPM
cerebral cortex: 1.1 nTPM
medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

peptidase inhibitor activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads R3HDML as an antibody target. Whether an autoantibody or antibody against R3HDML could matter depends on whether native R3HDML is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

R3HDML is annotated as secreted, so native R3HDML circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label R3HDML as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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