Seroatlas · Human Serome Atlas

QTRT2

Queuine tRNA-ribosyltransferase accessory subunit 2

Also known as: FLJ12960, QTRT2_HUMAN, QTRTD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H974
Gene
QTRT2
Ensembl
ENSG00000151576
Chromosome
3
Canonical length
415 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q9H974|QTRT2
     1  MKLSLTKVVN GCRLGKIKNL GKTGDHTMDI PGCLLYTKTG SAPHLTHHTL HNIHGVPAMA
    61  QLTLSSLAEH HEVLTEYKEG VGKFIGMPES LLYCSLHDPV SPCPAGYVTN KSVSVWSVAG
   121  RVEMTVSKFM AIQKALQPDW FQCLSDGEVS CKEATSIKRV RKSVDRSLLF LDNCLRLQEE
   181  SEVLQKSVII GVIEGGDVME ERLRSARETA KRPVGGFLLD GFQGNPTTLE ARLRLLSSVT
   241  AELPEDKPRL ISGVSRPDEV LECIERGVDL FESFFPYQVT ERGCALTFSF DYQPNPEETL
   301  LQQNGTQEEI KCMDQIKKIE TTGCNQEITS FEINLKEKKY QEDFNPLVRG CSCYCCKNHT
   361  RAYIHHLLVT NELLAGVLLM MHNFEHYFGF FHYIREALKS DKLAQLKELI HRQAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QTRT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 11 nTPM
  • spleen: 11 nTPM
  • tonsil: 11 nTPM
  • bone marrow: 11 nTPM
  • retina: 11 nTPM
  • breast: 9.5 nTPM

Single-cell type

  • epicardial cells: 84 nCPM
  • rod photoreceptor cells: 52 nCPM
  • cardiomyocytes: 49 nCPM
  • cone photoreceptor cells: 48 nCPM
  • choroid plexus epithelial cells: 46 nCPM
  • sertoli cells: 44 nCPM

Immune cell

  • myeloid DC: 19 nTPM
  • memory B-cell: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • classical monocyte: 15 nTPM
  • non-classical monocyte: 12 nTPM
  • naive B-cell: 11 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • white matter: 10 nTPM
  • hippocampal formation: 10 nTPM
  • basal ganglia: 9.7 nTPM
  • cerebral cortex: 9.7 nTPM
  • medulla oblongata: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QTRT2 as an antibody target. Whether an autoantibody or antibody against QTRT2 could matter depends on whether native QTRT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QTRT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QTRT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/QTRT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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