Seroatlas · Human Serome Atlas

QTRT1

Queuine tRNA-ribosyltransferase catalytic subunit 1

Also known as: TGT, TGT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXR0
Gene: QTRT1
Ensembl: ENSG00000213339
Chromosome: 19
Canonical length: 403 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q9BXR0|QTRT1
     1  MAGAATQASL ESAPRIMRLV AECSRSRARA GELWLPHGTV ATPVFMPVGT QATMKGITTE
    61  QLDALGCRIC LGNTYHLGLR PGPELIQKAN GLHGFMNWPH NLLTDSGGFQ MVSLVSLSEV
   121  TEEGVRFRSP YDGNETLLSP EKSVQIQNAL GSDIIMQLDD VVSSTVTGPR VEEAMYRSIR
   181  WLDRCIAAHQ RPDKQNLFAI IQGGLDADLR ATCLEEMTKR DVPGFAIGGL SGGESKSQFW
   241  RMVALSTSRL PKDKPRYLMG VGYATDLVVC VALGCDMFDC VFPTRTARFG SALVPTGNLQ
   301  LRKKVFEKDF GPIDPECTCP TCQKHSRAFL HALLHSDNTA ALHHLTVHNI AYQLQLMSAV
   361  RTSIVEKRFP DFVRDFMGAM YGDPTLCPTW ATDALASVGI TLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QTRT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

pancreas: 50 nTPM
liver: 28 nTPM
adrenal gland: 26 nTPM
ovary: 23 nTPM
basal ganglia: 22 nTPM
endometrium: 21 nTPM

Single-cell type

enteric stem cells: 281 nCPM
paneth cells: 255 nCPM
enteric transient amplifying cells: 241 nCPM
enterocytes: 216 nCPM
colonocytes: 192 nCPM
goblet cells: 174 nCPM

Immune cell

NK-cell: 44 nTPM
memory B-cell: 42 nTPM
naive B-cell: 41 nTPM
plasmacytoid DC: 40 nTPM
T-reg: 38 nTPM
MAIT T-cell: 37 nTPM

Brain region

cerebral cortex: 24 nTPM
hippocampal formation: 23 nTPM
thalamus: 22 nTPM
hypothalamus: 22 nTPM
white matter: 22 nTPM
basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA wobble guanine modification

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QTRT1 as an antibody target. Whether an autoantibody or antibody against QTRT1 could matter depends on whether native QTRT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QTRT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QTRT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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