Seroatlas · Human Serome Atlas

QRFP

Orexigenic neuropeptide QRFP

Also known as: 26RFa, OX26_HUMAN, P518, prepro-26RFa

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P83859
Gene
QRFP
Ensembl
ENSG00000188710
Chromosome
9
Canonical length
136 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>P83859|QRFP
     1  MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH SVWGSSRWLR
    61  ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF LPAAGEKTSG PLGNLAEELN
   121  GYSRKKGGFS FRFGRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QRFP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
2.1 nTPM

Expression across tissuesHPA

Tissue

  • colon: 2.1 nTPM
  • urinary bladder: 1.8 nTPM
  • pancreas: 1.3 nTPM
  • prostate: 1.2 nTPM
  • testis: 1.1 nTPM
  • blood vessel: 1 nTPM

Single-cell type

  • epicardial cells: 4.5 nCPM
  • retinal amacrine cells: 2.1 nCPM
  • salivary myoepithelial cells: 1.3 nCPM
  • fibro-adipogenic progenitors: 1.1 nCPM
  • müller glia: 1.1 nCPM
  • hofbauer cells: 1 nCPM

Immune cell

  • intermediate monocyte: 1 nTPM
  • classical monocyte: 0.5 nTPM
  • non-classical monocyte: 0.4 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • basal ganglia: 2.2 nTPM
  • cerebral cortex: 2.1 nTPM
  • pons: 2.1 nTPM
  • cerebellum: 2 nTPM
  • thalamus: 2 nTPM
  • white matter: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QRFP.

Disease | ImmuneIEDB

Conditions an epitope on QRFP was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.51
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Orexigenic neuropeptide QRFP/P518
  • Orexigenic neuropeptide Qrfp/P518

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QRFP as an antibody target. Whether an autoantibody or antibody against QRFP could matter depends on whether native QRFP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QRFP is annotated as secreted, so native QRFP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label QRFP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/QRFP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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