QPRT

Protein identityUniProt · HPA

UniProt accession

Q15274

Gene

QPRT

Ensembl

ENSG00000103485

Chromosome

16

Canonical length

297 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q15274|QPRT
     1  MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF
    61  DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA
   121  AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG
   181  VEKAVRAARQ AADFTLKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF
   241  PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QPRT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

221 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.1

gnomAD pLI

0

gnomAD missense Z

1.12

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 'de novo' NAD+ biosynthetic process from L-tryptophan
• NAD+ biosynthetic process
• quinolinate catabolic process

Molecular functions

• identical protein binding
• nicotinate-nucleotide diphosphorylase (carboxylating) activity

Cellular components

• catalytic complex
• cytoplasm
• cytosol
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• Aldolase-type TIM barrel
• Nicotinate phosphoribosyltransferase-like, C-terminal
• Quinolinate phosphoribosyl transferase, C-terminal
• Nicotinate-nucleotide pyrophosphorylase
• Quinolinate phosphoribosyl transferase, N-terminal
• Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD
• Quinolinate phosphoribosyl transferase, N-terminal domain superfamily
• Quinolinate phosphoribosyl transferase, C-terminal domain
• Quinolinate phosphoribosyl transferase, N-terminal domain

KeywordsUniProt

• Glycosyltransferase
• Pyridine nucleotide biosynthesis
• Transferase