Seroatlas · Human Serome Atlas

QPCTL

Glutaminyl-peptide cyclotransferase-like protein

Also known as: FLJ20084, QPCTL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXS2
Gene: QPCTL
Ensembl: ENSG00000011478
Chromosome: 19
Canonical length: 382 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q9NXS2|QPCTL
     1  MRSGGRGRPR LRLGERGLME PLLPPKRRLL PRVRLLPLLL ALAVGSAFYT IWSGWHRRTE
    61  ELPLGRELRV PLIGSLPEAR LRRVVGQLDP QRLWSTYLRP LLVVRTPGSP GNLQVRKFLE
   121  ATLRSLTAGW HVELDPFTAS TPLGPVDFGN VVATLDPRAA RHLTLACHYD SKLFPPGSTP
   181  FVGATDSAVP CALLLELAQA LDLELSRAKK QAAPVTLQLL FLDGEEALKE WGPKDSLYGS
   241  RHLAQLMESI PHSPGPTRIQ AIELFMLLDL LGAPNPTFYS HFPRTVRWFH RLRSIEKRLH
   301  RLNLLQSHPQ EVMYFQPGEP FGSVEDDHIP FLRRGVPVLH LISTPFPAVW HTPADTEVNL
   361  HPPTVHNLCR ILAVFLAEYL GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QPCTL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

liver: 8.6 nTPM
spleen: 7.9 nTPM
adrenal gland: 7.4 nTPM
pancreas: 7 nTPM
choroid plexus: 6.4 nTPM
pituitary gland: 6.4 nTPM

Single-cell type

plasma cells: 33 nCPM
thymocytes: 32 nCPM
pdcs: 32 nCPM
innate lymphoid cells: 31 nCPM
mast cells: 30 nCPM
b-cells: 22 nCPM

Immune cell

NK-cell: 1.4 nTPM
gdT-cell: 1.3 nTPM
basophil: 1.1 nTPM
neutrophil: 1 nTPM
MAIT T-cell: 0.9 nTPM
plasmacytoid DC: 0.9 nTPM

Brain region

cerebral cortex: 9.8 nTPM
pons: 9.6 nTPM
medulla oblongata: 9.3 nTPM
thalamus: 9 nTPM
choroid plexus: 8.7 nTPM
hippocampal formation: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

using glutaminyl-peptide cyclotransferase
peptidyl-pyroglutamic acid biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QPCTL as an antibody target. Whether an autoantibody or antibody against QPCTL could matter depends on whether native QPCTL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QPCTL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QPCTL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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