Seroatlas · Human Serome Atlas

QPCT

Glutaminyl-peptide cyclotransferase

Also known as: GCT, QC, QPCT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16769
Gene: QPCT
Ensembl: ENSG00000115828
Chromosome: 2
Canonical length: 361 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q16769|QPCT
     1  MAGGRHRRVV GTLHLLLLVA ALPWASRGVS PSASAWPEEK NYHQPAILNS SALRQIAEGT
    61  SISEMWQNDL QPLLIERYPG SPGSYAARQH IMQRIQRLQA DWVLEIDTFL SQTPYGYRSF
   121  SNIISTLNPT AKRHLVLACH YDSKYFSHWN NRVFVGATDS AVPCAMMLEL ARALDKKLLS
   181  LKTVSDSKPD LSLQLIFFDG EEAFLHWSPQ DSLYGSRHLA AKMASTPHPP GARGTSQLHG
   241  MDLLVLLDLI GAPNPTFPNF FPNSARWFER LQAIEHELHE LGLLKDHSLE GRYFQNYSYG
   301  GVIQDDHIPF LRRGVPVLHL IPSPFPEVWH TMDDNEENLD ESTIDNLNKI LQVFVLEYLH
   361  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QPCT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 162 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 162 nTPM
epididymis: 98 nTPM
bone marrow: 45 nTPM
hypothalamus: 35 nTPM
skin: 34 nTPM
pituitary gland: 26 nTPM

Single-cell type

melanocytes: 857 nCPM
neutrophils: 460 nCPM
pancreatic islet cells: 281 nCPM
decidual stromal cells: 129 nCPM
neutrophil progenitors: 112 nCPM
neuroendocrine cells: 106 nCPM

Immune cell

neutrophil: 1,537 nTPM
classical monocyte: 346 nTPM
total PBMC: 170 nTPM
myeloid DC: 125 nTPM
intermediate monocyte: 39 nTPM
basophil: 9.8 nTPM

Brain region

hypothalamus: 52 nTPM
pons: 24 nTPM
midbrain: 17 nTPM
cerebral cortex: 16 nTPM
thalamus: 15 nTPM
medulla oblongata: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QPCT.

Disease | ImmuneIEDB

Conditions an epitope on QPCT was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.94
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QPCT as an antibody target. Whether an autoantibody or antibody against QPCT could matter depends on whether native QPCT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QPCT is annotated as secreted, so native QPCT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label QPCT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...