Seroatlas · Human Serome Atlas

QNG1

Queuosine 5'-phosphate N-glycosylase/hydrolase

Also known as: C9orf64, MGC10999, QNG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T6V5
Gene: QNG1
Ensembl: ENSG00000165118
Chromosome: 9
Canonical length: 341 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable hydrolase activity. Involved in nucleoside salvage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q5T6V5|QNG1
     1  MDGLLNPRES SKFIAENSRD VFIDSGGVRR VAELLLAKAA GPELRVEGWK ALHELNPRAA
    61  DEAAVNWVFV TDTLNFSFWS EQDEHKCVVR YRGKTYSGYW SLCAAVNRAL DEGIPITSAS
   121  YYATVTLDQV RNILRSDTDV SMPLVEERHR ILNETGKILL EKFGGSFLNC VRESENSAQK
   181  LMHLVVESFP SYRDVTLFEG KRVSFYKRAQ ILVADTWSVL EGKGDGCFKD ISSITMFADY
   241  RLPQVLAHLG ALKYSDDLLK KLLKGEMLSY GDRQEVEIRG CSLWCVELIR DCLLELIEQK
   301  GEKPNGEINS ILLDYYLWDY AHDHREDMKG IPFHRIRCIY Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QNG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

liver: 23 nTPM
duodenum: 22 nTPM
small intestine: 21 nTPM
thyroid gland: 15 nTPM
parathyroid gland: 13 nTPM
kidney: 13 nTPM

Single-cell type

hepatocytes: 30 nCPM
extravillous trophoblasts: 28 nCPM
enterocytes: 22 nCPM
foveolar cells: 22 nCPM
adrenal medulla cells: 21 nCPM
alveolar cells type 1: 20 nCPM

Immune cell

non-classical monocyte: 13 nTPM
NK-cell: 13 nTPM
myeloid DC: 12 nTPM
intermediate monocyte: 12 nTPM
classical monocyte: 10 nTPM
eosinophil: 9.8 nTPM

Brain region

choroid plexus: 24 nTPM
white matter: 14 nTPM
midbrain: 13 nTPM
hypothalamus: 13 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleoside salvage
tRNA modification
tRNA queuosine(34) biosynthetic process from salvaged queuosine or its precursors
purine nucleobase salvage

Molecular functions

hydrolase activity
queuosine nucleosidase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Queuosine salvage protein family
Queuosine salvage protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QNG1 as an antibody target. Whether an autoantibody or antibody against QNG1 could matter depends on whether native QNG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QNG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QNG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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