Seroatlas · Human Serome Atlas

Q9N2K0

HERV-H_2q24.3 provirus ancestral Env polyprotein

Also known as: ENH1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9N2K0
Gene: Q9N2K0
Canonical length: 584 aa

OverviewNCBI Gene

No narrative summary is available for Q9N2K0 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q9N2K0|Q9N2K0
     1  MIFAGKAPSN TSTLMKFYSL LLYSLLFSFP FLCHPLPLPS YLHHTINLTH SLLAASNPSL
    61  VNNCWLCISL SSSAYTAVPA VQTDWATSPI SLHLRTSFNS PHLYPPEELI YFLDRSSKTS
   121  PDISHQQAAA LLRTYLKNLS PYINSTPPIF GPLTTQTTIP VAAPLCISWQ RPTGIPLGNL
   181  SPSRCSFTLH LRSPTTNINE TIGAFQLHIT DKPSINTDKL KNISSNYCLG RHLPCISLHP
   241  WLSSPCSSDS PPRPSSCLLI PSPENNSERL LVDTRRFLIH HENRTFPSTQ LPHQSPLQPL
   301  TAAALAGSLG VWVQDTPFST PSHLFTLHLQ FCLAQGLFFL CGSSTYMCLP ANWTGTCTLV
   361  FLTPKIQFAN GTEELPVPLM TPTQQKRVIP LIPLMVGLGL SASTVALGTG IAGISTSVMT
   421  FRSLSNDFSA SITDISQTLS VLQAQVDSLA AVVLQNRRGL DLLTAEKGGL CIFLNEECCF
   481  YLNQSGLVYD NIKKLKDRAQ KLANQASNYA EPPWALSNWM SWVLPIVSPL IPIFLLLLFG
   541  PCIFRLVSQF IQNRIQAITN HSIRQMFLLT SPQYHPLPQD LPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against Q9N2K0 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about Q9N2K0.

Disease | ImmuneIEDB

Conditions an epitope on Q9N2K0 was assayed in.

prostate cancer B cell
benign prostate phyllodes tumor B cell
lymphoepithelioma-like acinar prostate adenocarcinoma B cell

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads Q9N2K0 as an antibody target. Whether an autoantibody or antibody against Q9N2K0 could matter depends on whether native Q9N2K0 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

Q9N2K0 is annotated at the cell surface, where native Q9N2K0 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label Q9N2K0 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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