Seroatlas · Human Serome Atlas

Q9N2J8

HERV-H_2q24.1 provirus ancestral Env polyprotein

Also known as: ENH3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9N2J8
Gene: Q9N2J8
Canonical length: 555 aa

OverviewNCBI Gene

No narrative summary is available for Q9N2J8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q9N2J8|Q9N2J8
     1  MILAGRAPSN TSTLMKFYSL LLYSLLFSFP FLYHPLPLPS YLHHTINLTH SLPAASNPSL
    61  ANNCWLCISL SSSAYIAVPT LQTDRATSPV SLHLRTSFNS PHLYPPEELI YFLDRSSKTS
   121  PDISHQPAAA LLHIYLKNLS PYINSTPPIF GPLTTQTTIP VAAPLCISRQ RPTGIPLGNI
   181  SPSRCSFTLH LQSPTTHVTE TIGVFQLHII DKPSINTDKL KNVSSNYCLG RHLPYISLHP
   241  WLPSPCSSDS PPRPSSCLLT PSPQNNSERL LVDTQRFLIH HENRTSSSMQ LAHQSPLQPL
   301  TAAALAGSLG VWVQDTPFST PSHPFSLHLQ FCLTQGLFFL CGSSTYMCLP ANWTGTCTLV
   361  FLTPKIQFAN GTKELPVPLM TLTPQKRVIP LIPLMVGLGL SASTIALSTG IAGISTSVTT
   421  FRSPSNDFSA SITDISQTLS VLQAQVDSLA AVVLQNRRGL GLSILLNEEC CFYLNQSGLV
   481  YENIKKLKDR AQKLANQASN YAESPWALSN WMSWVLPILS PLIPIFLLLL FGPCIFHLVS
   541  QFIQNRIQAI TNHSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against Q9N2J8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads Q9N2J8 as an antibody target. Whether an autoantibody or antibody against Q9N2J8 could matter depends on whether native Q9N2J8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

Q9N2J8 is annotated at the cell surface, where native Q9N2J8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label Q9N2J8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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