Seroatlas · Human Serome Atlas

Q8IYB0

Putative uncharacterized protein MGC39545

Also known as: YK038_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYB0
Gene: Q8IYB0
Canonical length: 196 aa

OverviewNCBI Gene

No narrative summary is available for Q8IYB0 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q8IYB0|Q8IYB0
     1  MPSGEERRDR QKGRRAGCDT SSTPSNTAPR IPEPGAHPTA ARPATAQPPR SLLPPVCSKT
    61  IALPASAAAA SGSDTAGMRG LGKAPHSGEG HERGRGNSKM KACNNYQYGY LAKPDTSFWI
   121  KCRRWLLADA GRHTQRPFWT FRVSHSPLLE AEAGRPSDVS QLQLGSDLKP KMRRPAGELF
   181  SPKDAGWELD PAEKSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against Q8IYB0 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads Q8IYB0 as an antibody target. Whether an autoantibody or antibody against Q8IYB0 could matter depends on whether native Q8IYB0 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

Q8IYB0 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label Q8IYB0 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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