Q6P435
Putative uncharacterized SMG1-like protein
Also known as: SMG1L_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for Q6P435 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
159 residues, UniProt reviewed canonical sequence.
>Q6P435|Q6P435
1 MSRRAPGSRL SSGGTNYSRS WNDWQPRTDS ASADPGNLKY SSSRDRGGSS SYGLQPSNSA
61 VVSRQRHDDT RVHADIQNDE KGGYSVNGGS GENTYGRKSL GQELRVNNVT SPEFTSVQHG
121 SRALATKDMR KSQERSMSYC DESRLSNLLR RITREDDRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against Q6P435 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads Q6P435 as an antibody target. Whether an autoantibody or antibody against Q6P435 could matter depends on whether native Q6P435 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
Q6P435 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label Q6P435 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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