Seroatlas · Human Serome Atlas

PYY2

Putative peptide YY-2

Also known as: PYY2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRI6
Gene: PYY2
Canonical length: 33 aa

OverviewNCBI Gene

No narrative summary is available for PYY2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

33 residues, UniProt reviewed canonical sequence.

>Q9NRI6|PYY2
     1  MATVLLALLV YLGALVDAYP IKPEAPGEDA FLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYY2 as an antibody target. Whether an autoantibody or antibody against PYY2 could matter depends on whether native PYY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYY2 is annotated as secreted, so native PYY2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PYY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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