PYY
Peptide YY
Also known as: PYY_HUMAN, PYY1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P10082
- Gene
- PYY
- Ensembl
- ENSG00000131096
- Chromosome
- 17
- Canonical length
- 97 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>P10082|PYY
1 MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA SLRHYLNLVT
61 RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PYY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- colon: 66 nTPM
- rectum: 42 nTPM
- small intestine: 27 nTPM
- duodenum: 3 nTPM
- adrenal gland: 2 nTPM
- appendix: 1.4 nTPM
Single-cell type
- neuroendocrine cells: 21,712 nCPM
- renal collecting duct intercalated cells: 148 nCPM
- enteric transient amplifying cells: 147 nCPM
- endometrial luminal cells: 110 nCPM
- colonocytes: 47 nCPM
- endometrial glandular cells: 39 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.8 nTPM
- pons: 1.2 nTPM
- thalamus: 1.2 nTPM
- white matter: 1.2 nTPM
- basal ganglia: 1 nTPM
- hypothalamus: 1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.71
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.3
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- G protein-coupled receptor binding
- hormone activity
- neuropeptide hormone activity
- neuropeptide Y receptor binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PYY as an antibody target. Whether an autoantibody or antibody against PYY could matter depends on whether native PYY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PYY is annotated as secreted, so native PYY circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PYY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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