Seroatlas · Human Serome Atlas

PYGO2

Pygopus homolog 2

Also known as: PYGO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRQ0
Gene
PYGO2
Ensembl
ENSG00000163348
Chromosome
1
Canonical length
406 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable several functions, including histone acetyltransferase regulator activity; histone binding activity; and zinc ion binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including canonical Wnt signaling pathway; lens development in camera-type eye; and regulation of mammary gland epithelial cell proliferation. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9BRQ0|PYGO2
     1  MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT QGPAYSHLTE
    61  FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP FGGFRVQGGM AGQVPPGYST
   121  GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG
   181  QMMPGPVGGF GPMISPTMGQ PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN
   241  TSPFPGPDPG FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG
   301  GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC QKWFHRECTG
   361  MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL VAANDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYGO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 31 nTPM
  • adrenal gland: 29 nTPM
  • cerebellum: 27 nTPM
  • spleen: 26 nTPM
  • tonsil: 26 nTPM
  • parathyroid gland: 26 nTPM

Single-cell type

  • cardiomyocytes: 22 nCPM
  • adrenal medulla cells: 21 nCPM
  • breast lactating cells: 19 nCPM
  • cytotrophoblasts: 18 nCPM
  • breast hormone-responsive cells: 18 nCPM
  • differentiating spermatogonia: 18 nCPM

Immune cell

  • naive CD4 T-cell: 11 nTPM
  • eosinophil: 11 nTPM
  • memory CD8 T-cell: 11 nTPM
  • memory CD4 T-cell: 10 nTPM
  • MAIT T-cell: 10 nTPM
  • naive CD8 T-cell: 8.7 nTPM

Brain region

  • hypothalamus: 45 nTPM
  • white matter: 38 nTPM
  • midbrain: 36 nTPM
  • medulla oblongata: 36 nTPM
  • thalamus: 35 nTPM
  • basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
1.1
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PYGO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYGO2 as an antibody target. Whether an autoantibody or antibody against PYGO2 could matter depends on whether native PYGO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYGO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PYGO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PYGO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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