Seroatlas · Human Serome Atlas

PYCARD-AS1

Putative uncharacterized protein PYCARD-AS1

Also known as: PYAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: I3L0S3
Gene: PYCARD-AS1
Canonical length: 204 aa

OverviewNCBI Gene

No narrative summary is available for PYCARD-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>I3L0S3|PYCARD-AS1
     1  MRAHVAQHVS GELGAVGLQV EADQLVGEVQ GVHGQQRAPR DAPVALAQRH RQQLQLELLE
    61  LLGGQVLQRI QDGVARAPHG SRIPGRCRRS PRCSRRPGGS RLRGGTWTPR LPPTLVSRLP
   121  APVRCPPAKG ASLLHPWSPP TQASGLGPQA VGGRQDRALQ LACEVGPGRG PQRGSWVAPA
   181  CLWACTSGYR PETWAGSHWV YWST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYCARD-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYCARD-AS1 as an antibody target. Whether an autoantibody or antibody against PYCARD-AS1 could matter depends on whether native PYCARD-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYCARD-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PYCARD-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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