Seroatlas · Human Serome Atlas

PXMP4

Peroxisomal membrane protein 4

Also known as: PMP24, PXMP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6I8
Gene: PXMP4
Ensembl: ENSG00000101417
Chromosome: 20
Canonical length: 212 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoli fibrillar center,Peroxisomes

OverviewNCBI Gene

Predicted to act upstream of or within ether lipid metabolic process. Located in peroxisomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>Q9Y6I8|PXMP4
     1  MAAPPQLRAL LVVVNALLRK RRYHAALAVL KGFRNGAVYG AKIRAPHALV MTFLFRNGSL
    61  QEKLWAILQA TYIHSWNLAR FVFTYKGLRA LQSYIQGKTY PAHAFLAAFL GGILVFGENN
   121  NINSQINMYL LSRVLFALSR LAVEKGYIPE PRWDPFPLLT AVVWGLVLWL FEYHRSTLQP
   181  SLQSSMTYLY EDSNVWHDIS DFLVYNKSRP SN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PXMP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 14 nTPM
parathyroid gland: 14 nTPM
lung: 13 nTPM
breast: 11 nTPM
thyroid gland: 11 nTPM
skin: 10 nTPM

Single-cell type

alveolar cells type 2: 99 nCPM
late spermatids: 59 nCPM
transitional alveolar cells: 54 nCPM
breast lactating cells: 37 nCPM
lacrimal acinar cells: 34 nCPM
platelets: 33 nCPM

Immune cell

non-classical monocyte: 34 nTPM
intermediate monocyte: 22 nTPM
eosinophil: 18 nTPM
MAIT T-cell: 11 nTPM
naive CD8 T-cell: 11 nTPM
classical monocyte: 11 nTPM

Brain region

white matter: 17 nTPM
cerebral cortex: 15 nTPM
thalamus: 15 nTPM
basal ganglia: 14 nTPM
amygdala: 14 nTPM
hippocampal formation: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ether lipid metabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tim17/Tim22/Tim23/Pmp24 family
Peroxisomal membrane protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PXMP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PEX19

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PXMP4 as an antibody target. Whether an autoantibody or antibody against PXMP4 could matter depends on whether native PXMP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PXMP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PXMP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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