Seroatlas · Human Serome Atlas

PXK

PX domain-containing protein kinase-like protein

Also known as: FLJ20335, PXK_HUMAN, Slob

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7A4
Gene
PXK
Ensembl
ENSG00000168297
Chromosome
3
Canonical length
578 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q7Z7A4|PXK
     1  MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
    61  LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
   121  PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
   181  ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
   241  AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
   301  CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
   361  PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
   421  IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
   481  KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
   541  SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PXK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 122 nTPM
  • midbrain: 77 nTPM
  • hippocampal formation: 69 nTPM
  • bone marrow: 69 nTPM
  • thyroid gland: 59 nTPM
  • basal ganglia: 55 nTPM

Single-cell type

  • oligodendrocytes: 825 nCPM
  • neutrophils: 569 nCPM
  • renal collecting duct intercalated cells: 353 nCPM
  • neutrophil progenitors: 256 nCPM
  • monocyte progenitors: 154 nCPM
  • oligodendrocyte progenitor cells: 130 nCPM

Immune cell

  • neutrophil: 74 nTPM
  • naive B-cell: 70 nTPM
  • eosinophil: 69 nTPM
  • memory B-cell: 63 nTPM
  • non-classical monocyte: 58 nTPM
  • classical monocyte: 45 nTPM

Brain region

  • white matter: 645 nTPM
  • medulla oblongata: 333 nTPM
  • basal ganglia: 332 nTPM
  • pons: 323 nTPM
  • midbrain: 275 nTPM
  • cerebral cortex: 260 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.01
gnomAD missense Z
1.09
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PXK as an antibody target. Whether an autoantibody or antibody against PXK could matter depends on whether native PXK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PXK is annotated at the cell surface, where native PXK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PXK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PXK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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