PXDNL

Protein identityUniProt · HPA

UniProt accession

A1KZ92

Gene

PXDNL

Ensembl

ENSG00000147485

Chromosome

8

Canonical length

1463 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Secretome location

Intracellular and membrane

OverviewNCBI Gene

Predicted to enable heme binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to be located in endoplasmic reticulum; extracellular region; and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1463 residues, UniProt reviewed canonical sequence.

>A1KZ92|PXDNL
     1  MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ QTTVLDLRFN
    61  RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL LYLYLYKNEI HALDKQTFKG
   121  LISLEHLYIH FNQLEMLQPE TFGDLLRLER LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN
   181  ALVCDCDLMW LGELLQGFAQ HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP
   241  QDVEVPSGNT VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ
   301  GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE CMATGHPHPL
   361  ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA NNSHGTVQAA ANIIVQAPPQ
   421  FTVTPKDQVV LEEHAVEWLC EADGNPPPVI VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ
   481  HDQGQYECQA VSSLGVKKVS VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP
   541  IITWNKEGVQ ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI
   601  QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP RDPLIVEMAR
   661  AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL SLIANLSGCT ARRPLPNCSN
   721  RCFHAKYRAH DGTCNNLQQP TWGAALTAFA RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP
   781  RLVATVWARA AAVTPDHSYT RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP
   841  PCFPMNTRHA DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY
   901  GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE SPCFLAGDHR
   961  ANEHLALAAM HTLWFREHNR MATELSALNP HWEGNTVYQE ARKIVGAELQ HITYSHWLPK
  1021  VLGDPGTRML RGYRGYNPNV NAGIINSFAT AAFRFGHTLI NPILYRLNAT LGEISEGHLP
  1081  FHKALFSPSR IIKEGGIDPV LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT
  1141  IIQRGRDHGI PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL
  1201  MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ ASLSRVLCDN
  1261  GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA DCRSRGQFRA VTQESQKKRS
  1321  AQYSYPVDKD MELSHLRSRQ QDKIYVGEDA RNVTVLAKTK FSQDFSTFAA EIQETITALR
  1381  EQINKLEARL RQAGCTDVRG VPRKAEERWM KEDCTHCICE SGQVTCVVEI CPPAPCPSPE
  1441  LVKGTCCPVC RDRGMPSDSP EKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PXDNL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

43 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.09

gnomAD pLI

0

gnomAD missense Z

-0.2

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• basement membrane assembly
• hydrogen peroxide catabolic process
• response to oxidative stress
• system development

Molecular functions

• endonuclease activity
• heme binding
• hydrolase activity
• metal ion binding
• peroxidase activity

Cellular components

• endoplasmic reticulum
• extracellular matrix
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Cysteine-rich flanking region, C-terminal
• VWFC domain
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Haem peroxidase superfamily
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Haem peroxidase, animal-type
• Leucine-rich repeat domain superfamily
• Peroxidasin, peroxidase domain
• Immunoglobulin-like domain superfamily
• Haem peroxidase domain superfamily, animal type
• Animal haem peroxidase
• Immunoglobulin I-set domain
• Leucine rich repeat
• Immunoglobulin domain
• VWC2L-like domain

KeywordsUniProt

• Calcium
• Cell membrane
• Cytoplasm
• Disulfide bond
• Endonuclease
• Endoplasmic reticulum
• Glycoprotein
• Heme
• Hydrolase
• Immunoglobulin domain
• Iron
• Leucine-rich repeat
• Membrane
• Metal-binding
• Nuclease
• Oxidoreductase
• Phosphoprotein
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of PXDNL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PXDN